A static magnetic field attenuates lipopolysaccharide-induced neuro-inflammatory response via IL-6-mediated pathway

Li Kuo Shen, Haw-Ming Huang, Po Chieh Yang, Yung-Kai Huang, Peter Da-yun Wang, Ting-Kai Leung, Chi-Jen Chen, Wei-Jen Chang

研究成果: 雜誌貢獻文章

5 引文 斯高帕斯(Scopus)

摘要

An effective method for controlling brain damage and neurodegeneration caused by inflammation remains elusive. Down-expression of the lipopolysaccharide (LPS)-induced inflammatory cytokines resulting in endotoxin tolerance is reported as an alternative anti-infection treatment. Nonetheless, because the dosage and action site are hard to control, endotoxin tolerance caused by low-dose LPS injection in brain tissue may induce side effects. The aim of this study was to test the hypothesis that static magnetic fields (SMF) stimulate endotoxin tolerance in brain tissue. In this study, survival rate and pathological changes in brain tissues of LPS-challenged mice were examined with and without SMF treatment. In addition, the effects of SMF exposure on growth rate and cytokine expression of LPS-challenged BV-2 microglia cells were monitored. Our results showed that SMF pre-exposure had positive effects on the survival rate and histological outcomes of LPS-treated mice. Furthermore, SMF exposure significantly decreased IL-6 expression in BV-2 cells (p
原文英語
頁(從 - 到)132-138
頁數7
期刊Electromagnetic Biology and Medicine
33
發行號2
DOIs
出版狀態已發佈 - 2014

ASJC Scopus subject areas

  • Biophysics
  • Medicine (miscellaneous)
  • Medicine(all)

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