A simple procedure for preparation of N-thiazolyl and N-thiadiazolylcantharidinimides and evaluation of their cytotoxicities against human hepatocellular carcinoma cells

Lin Pen-Yuan, Shi Sheng-Jie, Shu Hsien-Liang, Chen Hsue-Fen, Lin Chiung-Chang, Liu Pong-Chun, Leng-Fang Wang

研究成果: 雜誌貢獻文章同行評審

35 引文 斯高帕斯(Scopus)

摘要

We made an effort to prepare effective cantharidinimides by heating the reactants 1 and 2a-j to 200°C with toluene and triethylamine to provide 10 N-thiazolyl- and N-thiadiazolylcantharidinimides 3a-j in high yields of 48-91%. All of the synthetic compounds were tested for their capability to suppress growth of the human hepatocellular carcinoma cell lines, SK-Hep-1 and Hep 3B. The results showed that compound 3f was the most potent, and it was more cytotoxic than cantharidin.
原文英語
頁(從 - 到)266-272
頁數7
期刊Bioorganic Chemistry
28
發行號5
DOIs
出版狀態已發佈 - 2000

ASJC Scopus subject areas

  • 生物化學
  • 分子生物學
  • 有機化學
  • 藥物發現

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