A Role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala

Chih Hung Lin, Shiu Hwa Yeh, Chia Ho Lin, Kwok Tung Lu, Tzeng Horng Leu, Wen Chang Chang, Po Wu Gean

研究成果: 雜誌貢獻文章同行評審

299 引文 斯高帕斯(Scopus)

摘要

Western blot analysis of neuronal tissues taken from fear-conditioned rats showed a selective activation of phosphatidylinositol 3-kinase (PI-3 kinase) in the amygdala. PI-3 kinase was also activated in response to long-term potentiation (LTP)-inducing tetanic stimulation. PI-3 kinase inhibitors blocked tetanus-induced LTP as well as PI-3 kinase activation. In parallel, these inhibitors interfered with long-term fear memory while leaving short-term memory intact. Tetanus and forskolin-induced activation of mitogen-activated protein kinase (MAPK) was blocked by PI-3 kinase inhibitors, which also inhibited cAMP response element binding protein (CREB) phosphorylation. These results provide novel evidence of a requirement of PI-3 kinase activation in the amygdala for synaptic plasticity and memory consolidation, and this activation may occur at a point upstream of MAPK activation.

原文英語
頁(從 - 到)841-851
頁數11
期刊Neuron
31
發行號5
DOIs
出版狀態已發佈 - 九月 13 2001
對外發佈Yes

ASJC Scopus subject areas

  • Neuroscience(all)

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