A review of the epidemiologic literature on the role of environmental arsenic exposure and cardiovascular diseases

Chih Hao Wang, Chuhsing Kate Hsiao, Chi Ling Chen, Lin I. Hsu, Hung Yi Chiou, Shu Yuan Chen, Yu Mei Hsueh, Meei Maan Wu, Chien Jen Chen

研究成果: 雜誌貢獻文章

159 引文 (Scopus)

摘要

Cardiovascular disease is the leading cause of mortality worldwide. Arsenic is a ubiquitous metalloid in the crust of the earth. Chronic arsenic poisoning is becoming an emerging epidemic in Asia. Epidemiological studies have shown that chronic arsenic poisoning through ingestion of arsenic-contaminated water is associated with various cardiovascular diseases in dose-response relationships. These cardiovascular disorders include carotid atherosclerosis detected by ultrasonography, impaired microcirculation, prolonged QT interval and increased QT dispersion in electrocardiography, and clinical outcomes such as hypertension, blackfoot disease (a unique peripheral vascular disease endemic in southwestern Taiwan), coronary artery disease and cerebral infarction. Chronic arsenic poisoning is an independent risk factor for cardiovascular disease. The adverse cardiovascular effects of long-term arsenic exposure may be persistent and/or irreversible. Arsenic-induced cardiovascular diseases in human population may result from the interaction among genetic, environment and nutritional factors. The major adverse cardiovascular effect of chronic arsenic poisoning has been established qualitatively and quantitatively in the high arsenic exposure areas, but the low-dose effect of arsenic on cardiovascular diseases remains to be explored. Cardiovascular death is the major cause of mortality worldwide, and a small increased risk may imply a large quantity of excess mortality.

原文英語
頁(從 - 到)315-326
頁數12
期刊Toxicology and Applied Pharmacology
222
發行號3
DOIs
出版狀態已發佈 - 八月 1 2007

指紋

Environmental Exposure
Arsenic
Arsenic Poisoning
Cardiovascular Diseases
Mortality
Metalloids
Nutrigenomics
Carotid Artery Diseases
Peripheral Vascular Diseases
Cerebral Infarction
Microcirculation
Taiwan
Epidemiologic Studies
Coronary Artery Disease
Ultrasonography
Electrocardiography
Eating
Hypertension
Water
Population

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

引用此文

A review of the epidemiologic literature on the role of environmental arsenic exposure and cardiovascular diseases. / Wang, Chih Hao; Hsiao, Chuhsing Kate; Chen, Chi Ling; Hsu, Lin I.; Chiou, Hung Yi; Chen, Shu Yuan; Hsueh, Yu Mei; Wu, Meei Maan; Chen, Chien Jen.

於: Toxicology and Applied Pharmacology, 卷 222, 編號 3, 01.08.2007, p. 315-326.

研究成果: 雜誌貢獻文章

Wang, Chih Hao ; Hsiao, Chuhsing Kate ; Chen, Chi Ling ; Hsu, Lin I. ; Chiou, Hung Yi ; Chen, Shu Yuan ; Hsueh, Yu Mei ; Wu, Meei Maan ; Chen, Chien Jen. / A review of the epidemiologic literature on the role of environmental arsenic exposure and cardiovascular diseases. 於: Toxicology and Applied Pharmacology. 2007 ; 卷 222, 編號 3. 頁 315-326.
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