A prospective study of glucose homeostasis in quetiapine-treated schizophrenic patients by using the intravenous glucose tolerance test

Chun Hsin Chen, Tsang Yaw Lin, Tzu Ting Chen, Vincent Chin Hung Chen, Ni Chi Lin, Wen Chuan Shao, Mong Liang Lu

研究成果: 雜誌貢獻文章同行評審

13 引文 斯高帕斯(Scopus)

摘要

Increasing attention has been paid recently to the potential diabetogenic effect of second-generation antipsychotics (SGAs). The objective of this prospective study was to evaluate the effects of quetiapine treatment on pancreatic beta-cell function in SGA-naïve schizophrenic patients. Seventeen schizophrenic subjects completed an eight-week trial. The metabolic parameters were assessed at weeks 0, 2, 4, and 8. We measured glucose homeostasis with the intravenous glucose tolerance test. After the eight-week treatment, body weight and body mass index showed to be significantly increased compared to those at baseline. No significant changes were found in serum levels of fasting glucose, insulin, total cholesterol, and high-density lipoprotein. Insulin resistance and insulin secretion were significantly increased. Incidences of clinically significant weight gain and treatment-emergent metabolic syndrome were 11.8% and 11.8%, respectively. This study result confirms the association of quetiapine treatment and impairment of glucose homeostasis in schizophrenic patients.

原文英語
頁(從 - 到)965-969
頁數5
期刊Progress in Neuro-Psychopharmacology and Biological Psychiatry
35
發行號4
DOIs
出版狀態已發佈 - 六月 1 2011

ASJC Scopus subject areas

  • 生物精神病學
  • 藥理

指紋

深入研究「A prospective study of glucose homeostasis in quetiapine-treated schizophrenic patients by using the intravenous glucose tolerance test」主題。共同形成了獨特的指紋。

引用此