A prospective randomized study of brain tissue oxygen pressure-guided management in moderate and severe traumatic brain injury patients

Chien Min Lin, Ming Chin Lin, Sheng Jean Huang, Cheng Kuei Chang, Dan Ping Chao, Tai Ngar Lui, Hsin I. Ma, Ming Ying Liu, Wen Yuh Chung, Yang Hsin Shih, Shin Han Tsai, Hung Yi Chiou, Mau Roung Lin, Sen Li Jen, Li Wei, Chung-Che Wu, En Yuan Lin, Kuo Hsing Liao, Yung Hsiao Chiang, Wen Ta ChiuJia Wei Lin

研究成果: 雜誌貢獻文章

11 引文 (Scopus)

摘要

The purpose of this study was to compare the effect of PbtOguided therapy with traditional intracranial pressure- (ICP-) guided treatment on the management of cerebral variables, therapeutic interventions, survival rates, and neurological outcomes of moderate and severe traumatic brain injury (TBI) patients. From 2009 to 2010, TBI patients with a Glasgow coma scale 20 mmHg), and 27 patients were treated with ICP-guided therapy (ICP <20 mmHg and CPP > 60 mmHg) in the neurosurgical intensive care unit (NICU); demographic characteristics were similar across groups. The survival rate in the PbtOguided group was also significantly increased at 3 and 6 months after injury. Moreover, there was a significant correlation between the PbtOsignal and Glasgow outcome scale-extended in patients from 1 to 6 months after injury. This finding demonstrates that therapy directed by PbtOmonitoring is valuable for the treatment of patients with moderate and severe TBI and that increasing PaOto 150 mmHg may be efficacious for preventing cerebral hypoxic events after brain trauma.
原文英語
文章編號529580
期刊BioMed Research International
2015
DOIs
出版狀態已發佈 - 2015

指紋

Brain
Prospective Studies
Tissue
Oxygen
Pressure
Intracranial Pressure
Intensive care units
Therapeutics
Survival Rate
Glasgow Outcome Scale
Glasgow Coma Scale
Wounds and Injuries
Intensive Care Units
Traumatic Brain Injury
Demography

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

引用此文

A prospective randomized study of brain tissue oxygen pressure-guided management in moderate and severe traumatic brain injury patients. / Lin, Chien Min; Lin, Ming Chin; Huang, Sheng Jean; Chang, Cheng Kuei; Chao, Dan Ping; Lui, Tai Ngar; Ma, Hsin I.; Liu, Ming Ying; Chung, Wen Yuh; Shih, Yang Hsin; Tsai, Shin Han; Chiou, Hung Yi; Lin, Mau Roung; Jen, Sen Li; Wei, Li; Wu, Chung-Che; Lin, En Yuan; Liao, Kuo Hsing; Chiang, Yung Hsiao; Chiu, Wen Ta; Lin, Jia Wei.

於: BioMed Research International, 卷 2015, 529580, 2015.

研究成果: 雜誌貢獻文章

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abstract = "The purpose of this study was to compare the effect of PbtOguided therapy with traditional intracranial pressure- (ICP-) guided treatment on the management of cerebral variables, therapeutic interventions, survival rates, and neurological outcomes of moderate and severe traumatic brain injury (TBI) patients. From 2009 to 2010, TBI patients with a Glasgow coma scale 20 mmHg), and 27 patients were treated with ICP-guided therapy (ICP <20 mmHg and CPP > 60 mmHg) in the neurosurgical intensive care unit (NICU); demographic characteristics were similar across groups. The survival rate in the PbtOguided group was also significantly increased at 3 and 6 months after injury. Moreover, there was a significant correlation between the PbtOsignal and Glasgow outcome scale-extended in patients from 1 to 6 months after injury. This finding demonstrates that therapy directed by PbtOmonitoring is valuable for the treatment of patients with moderate and severe TBI and that increasing PaOto 150 mmHg may be efficacious for preventing cerebral hypoxic events after brain trauma.",
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AU - Shih, Yang Hsin

AU - Tsai, Shin Han

AU - Chiou, Hung Yi

AU - Lin, Mau Roung

AU - Jen, Sen Li

AU - Wei, Li

AU - Wu, Chung-Che

AU - Lin, En Yuan

AU - Liao, Kuo Hsing

AU - Chiang, Yung Hsiao

AU - Chiu, Wen Ta

AU - Lin, Jia Wei

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