The purpose of this study was to compare the effect of PbtOguided therapy with traditional intracranial pressure- (ICP-) guided treatment on the management of cerebral variables, therapeutic interventions, survival rates, and neurological outcomes of moderate and severe traumatic brain injury (TBI) patients. From 2009 to 2010, TBI patients with a Glasgow coma scale 20 mmHg), and 27 patients were treated with ICP-guided therapy (ICP <20 mmHg and CPP > 60 mmHg) in the neurosurgical intensive care unit (NICU); demographic characteristics were similar across groups. The survival rate in the PbtOguided group was also significantly increased at 3 and 6 months after injury. Moreover, there was a significant correlation between the PbtOsignal and Glasgow outcome scale-extended in patients from 1 to 6 months after injury. This finding demonstrates that therapy directed by PbtOmonitoring is valuable for the treatment of patients with moderate and severe TBI and that increasing PaOto 150 mmHg may be efficacious for preventing cerebral hypoxic events after brain trauma.
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)