A prospective randomized comparative trial showing that omeprazole prevents rebleeding in patients with bleeding peptic ulcer after successful endoscopic therapy

Hwai Jeng Lin, Wen Ching Lo, Fa Yauh Lee, Chin Lin Perng, Guan Ying Tseng

研究成果: 雜誌貢獻文章同行評審

231 引文 斯高帕斯(Scopus)

摘要

Background: A blood clot in a peptic ulcer is unstable in a low pH environment. The use of omeprazole may prevent rebleeding by elevating intragastric pH in patients with bleeding peptic ulcer after hemostasis has been achieved. Objectives: To assess the influence of using omeprazole and cimetidine on 24-hour intragastric pH and to determine their ability to prevent rebleeding after having achieved initial hemostasis in patients with active bleeding or nonbleeding visible vessels. Methods: One hundred patients with bleeding peptic ulcers who had obtained initial hemostasis were enrolled in this randomized comparative trial. In the cimetidine group (n=50), a 300- mg intravenous bolus of cimetidine was given, followed by a 1200-mg continuous infusion daily for 3 days. Thereafter, 400 mg of cimetidine was given orally twice daily for 2 months. In the omeprazole group (n=50), a 40- mg intravenous bolus of omeprazole was given, followed by 160 mg of continuous infusion daily for 3 days. Thereafter, 20 mg of omeprazole was given orally once daily for 2 months. A pH meter was inserted in each patient's fundus under fluoroscopic guidance after the intravenous bolus of cimetidine or omeprazole had been administered. Results: The stigmata of recent hemorrhage before endoscopic therapy in the omeprazole and cimetidine groups were, respectively, spurting (9 vs 12) oozing (4 vs 9), and nonbleeding visible vessel (37 vs 29) (P>.05). The duration of intragastric pH higher than 6.0 was longer in the omeprazole group (mean[±SD], 84.4%±22.9%) than that of the cimetidine group (mean[±SD], 53.5%±32.3%) (P

原文英語
頁(從 - 到)54-58
頁數5
期刊Archives of Internal Medicine
158
發行號1
DOIs
出版狀態已發佈 - 一月 12 1998
對外發佈

ASJC Scopus subject areas

  • 內科學

指紋

深入研究「A prospective randomized comparative trial showing that omeprazole prevents rebleeding in patients with bleeding peptic ulcer after successful endoscopic therapy」主題。共同形成了獨特的指紋。

引用此