A promising biomimetic surface enhances cell proliferation and adhesion ability for promoting early-stage osseointegration

Fang Yu Fan, Chia Jen Wu, Yung Chieh Cho, Erwan Sugiatno, Hsin Hua Chou, Keng Liang Ou, Yi Jung Lu, Bai Hung Huang, Muhammad Ruslin, Mao Suan Huang

研究成果: 雜誌貢獻文章

摘要

The surface characteristics, microstructures, and biocompatibility of the metal titanium oxide (TiO) film cross-linked with different self-assembled monolayers (SAMs) of phosphonate were elucidated through scanning electron microscopy, atomic force microscopy, X-ray diffractometry, transmission electron microscopy, and in vitro cell culturing assay in the present study. It was found that a relatively uniform and flat SAM with a roughness of 3.09 ± 0.32 nm can be formed on the specimen surface after cross-linking with 11-phosphonoundecanoic acid solution (PUA-SAM/TiO). The microstructures of the investigated SAMs were composed of amorphous structure. Moreover, analytical results from the biocompatibility assay and cell adhesion response also demonstrated that the PUA-SAM/TiO specimen possesses better osteoblast-like MG-63 cell adhesion and proliferation ability at the early time point of culturing (24 h). Thus, these findings reveal that the formation of SAM of phosphonate as the targeted biomimetic surface could potentially promote early-stage osseointegration for biomedical Ti implants.
原文英語
文章編號155905
期刊Journal of Alloys and Compounds
844
DOIs
出版狀態已發佈 - 十二月 5 2020

ASJC Scopus subject areas

  • Mechanics of Materials
  • Mechanical Engineering
  • Metals and Alloys
  • Materials Chemistry

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