A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor

Tzu Hsuan Wong, Chon Lin Lee, Hsiang Han Su, Chin Lai Lee, Chao Chien Wu, Chin Chou Wang, Chau Chyun Sheu, Ruay Sheng Lai, Sum Yee Leung, Chi Cheng Lin, Yu Feng Wei, Chien Jen Wang, Yu Chun Lin, Hua Ling Chen, Ming Shyan Huang, Jeng Hsien Yen, Shau Ku Huang, Jau Ling Suen

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8 引文 斯高帕斯(Scopus)

摘要

Chronic exposure to ambient polycyclic aromatic hydrocarbons (PAHs) is associated with asthma, but its regulatory mechanisms remain incompletely defined. We report herein that elevated levels of urinary 1-hydroxypyrene, a biomarker of PAH exposure, were found in asthmatic subjects (n = 39) as compared to those in healthy subjects (n = 43) living in an industrial city of Taiwan, where indeno[1,2,3-cd]pyrene (IP) was found to be a prominent PAH associated with ambient PM2.5. In a mouse model, intranasal exposure of mice with varying doses of IP significantly enhanced antigen-induced allergic inflammation, including increased airway eosinophilia, Th2 cytokines, including IL-4 and IL-5, as well as antigen-specific IgE level, which was absent in dendritic cell (DC)-specific aryl hydrocarbon receptor (AhR)-null mice. Mechanistically, IP treatment significantly altered DC's function, including increased level of pro-inflammatory IL-6 and decreased generation of anti-inflammatory IL-10. The IP's effect was lost in DCs from mice carrying an AhR-mutant allele. Taken together, these results suggest that chronic exposure to environmental PAHs may pose a significant risk for asthma, in which IP, a prominent ambient PAH in Taiwan, was shown to enhance the severity of allergic lung inflammation in mice through, at least in part, its ability in modulating DC's function in an AhR-dependent manner.

原文英語
文章編號5198
期刊Scientific Reports
8
發行號1
DOIs
出版狀態已發佈 - 十二月 1 2018
對外發佈Yes

ASJC Scopus subject areas

  • General

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