A programmable high-voltage compliance neural stimulator for deep brain stimulation in vivo

Cihun Siyong Alex Gong, Hsin Yi Lai, Sy Han Huang, Yu Chun Lo, Nicole Lee, Pin Yuan Chen, Po Hsun Tu, Chia Yen Yang, James Chang Chieh Lin, You Yin Chen

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)

摘要

Deep brain stimulation (DBS) is one of the most effective therapies for movement and other disorders. The DBS neurosurgical procedure involves the implantation of a DBS device and a battery-operated neurotransmitter, which delivers electrical impulses to treatment targets through implanted electrodes. The DBS modulates the neuronal activities in the brain nucleus for improving physiological responses as long as an electric discharge above the stimulation threshold can be achieved. In an effort to improve the performance of an implanted DBS device, the device size, implementation cost, and power efficiency are among the most important DBS device design aspects. This study aims to present preliminary research results of an efficient stimulator, with emphasis on conversion efficiency. The prototype stimulator features high-voltage compliance, implemented with only a standard semiconductor process, without the use of extra masks in the foundry through our proposed circuit structure. The results of animal experiments, including evaluation of evoked responses induced by thalamic electrical stimuli with our fabricated chip, were shown to demonstrate the proof of concept of our design.
原文英語
頁(從 - 到)12700-12719
頁數20
期刊Sensors (Switzerland)
15
發行號6
DOIs
出版狀態已發佈 - 五月 28 2015
對外發佈Yes

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics
  • Analytical Chemistry
  • Biochemistry

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    Gong, C. S. A., Lai, H. Y., Huang, S. H., Lo, Y. C., Lee, N., Chen, P. Y., Tu, P. H., Yang, C. Y., Lin, J. C. C., & Chen, Y. Y. (2015). A programmable high-voltage compliance neural stimulator for deep brain stimulation in vivo. Sensors (Switzerland), 15(6), 12700-12719. https://doi.org/10.3390/s150612700