A programmable high-voltage compliance neural stimulator for deep brain stimulation in vivo

Cihun Siyong Alex Gong, Hsin Yi Lai, Sy Han Huang, Yu Chun Lo, Nicole Lee, Pin Yuan Chen, Po Hsun Tu, Chia Yen Yang, James Chang Chieh Lin, You Yin Chen

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

Deep brain stimulation (DBS) is one of the most effective therapies for movement and other disorders. The DBS neurosurgical procedure involves the implantation of a DBS device and a battery-operated neurotransmitter, which delivers electrical impulses to treatment targets through implanted electrodes. The DBS modulates the neuronal activities in the brain nucleus for improving physiological responses as long as an electric discharge above the stimulation threshold can be achieved. In an effort to improve the performance of an implanted DBS device, the device size, implementation cost, and power efficiency are among the most important DBS device design aspects. This study aims to present preliminary research results of an efficient stimulator, with emphasis on conversion efficiency. The prototype stimulator features high-voltage compliance, implemented with only a standard semiconductor process, without the use of extra masks in the foundry through our proposed circuit structure. The results of animal experiments, including evaluation of evoked responses induced by thalamic electrical stimuli with our fabricated chip, were shown to demonstrate the proof of concept of our design.
原文英語
頁(從 - 到)12700-12719
頁數20
期刊Sensors (Switzerland)
15
發行號6
DOIs
出版狀態已發佈 - 五月 28 2015
對外發佈Yes

指紋

Deep Brain Stimulation
stimulation
Compliance
brain
high voltages
Brain
Electric potential
Equipment and Supplies
Neurosurgical Procedures
Equipment Design
physiological responses
Implanted Electrodes
Semiconductors
neurotransmitters
Movement Disorders
Electric discharges
foundries
Masks
electric discharges
power efficiency

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics
  • Analytical Chemistry
  • Biochemistry

引用此文

Gong, C. S. A., Lai, H. Y., Huang, S. H., Lo, Y. C., Lee, N., Chen, P. Y., ... Chen, Y. Y. (2015). A programmable high-voltage compliance neural stimulator for deep brain stimulation in vivo. Sensors (Switzerland), 15(6), 12700-12719. https://doi.org/10.3390/s150612700

A programmable high-voltage compliance neural stimulator for deep brain stimulation in vivo. / Gong, Cihun Siyong Alex; Lai, Hsin Yi; Huang, Sy Han; Lo, Yu Chun; Lee, Nicole; Chen, Pin Yuan; Tu, Po Hsun; Yang, Chia Yen; Lin, James Chang Chieh; Chen, You Yin.

於: Sensors (Switzerland), 卷 15, 編號 6, 28.05.2015, p. 12700-12719.

研究成果: 雜誌貢獻文章

Gong, CSA, Lai, HY, Huang, SH, Lo, YC, Lee, N, Chen, PY, Tu, PH, Yang, CY, Lin, JCC & Chen, YY 2015, 'A programmable high-voltage compliance neural stimulator for deep brain stimulation in vivo', Sensors (Switzerland), 卷 15, 編號 6, 頁 12700-12719. https://doi.org/10.3390/s150612700
Gong, Cihun Siyong Alex ; Lai, Hsin Yi ; Huang, Sy Han ; Lo, Yu Chun ; Lee, Nicole ; Chen, Pin Yuan ; Tu, Po Hsun ; Yang, Chia Yen ; Lin, James Chang Chieh ; Chen, You Yin. / A programmable high-voltage compliance neural stimulator for deep brain stimulation in vivo. 於: Sensors (Switzerland). 2015 ; 卷 15, 編號 6. 頁 12700-12719.
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