A powerful and robust test in genetic association studies

Kuang Fu Cheng, Jen Yu Lee

研究成果: 雜誌貢獻文章

1 引文 (Scopus)

摘要

There are several well-known single SNP tests presented in the literature for detecting gene-disease association signals. Having in place an efficient and robust testing process across all genetic models would allow a more comprehensive approach to analysis. Although some studies have shown that it is possible to construct such a test when the variants are common and the genetic model satisfies certain conditions, the model conditions are too restrictive and in general difficult to verify. In this paper, we propose a powerful and robust test without assuming any model restrictions. Our test is based on the selected 2 × 2 tables derived from the usual 2 × 3 table. By signals from these tables, we show through simulations across a wide range of allele frequencies and genetic models that this approach may produce a test which is almost uniformly most powerful in the analysis of low- and high-frequency variants. Two cancer studies are used to demonstrate applications of the proposed test.

原文英語
頁(從 - 到)38-46
頁數9
期刊Human Heredity
78
發行號1
DOIs
出版狀態已發佈 - 2014

指紋

Genetic Models
Genetic Association Studies
Gene Frequency
Single Nucleotide Polymorphism
Genes
Neoplasms

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics
  • Medicine(all)

引用此文

A powerful and robust test in genetic association studies. / Cheng, Kuang Fu; Lee, Jen Yu.

於: Human Heredity, 卷 78, 編號 1, 2014, p. 38-46.

研究成果: 雜誌貢獻文章

Cheng, Kuang Fu ; Lee, Jen Yu. / A powerful and robust test in genetic association studies. 於: Human Heredity. 2014 ; 卷 78, 編號 1. 頁 38-46.
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