A potential for granulocyte-colony stimulating factor for use as a prophylactic agent for heatstroke in rats

Ming Chi Yung, Chuan Chih Hsu, Chieh Yi Kang, Chia Li Lin, Shu Ling Chang, Jhi Joung Wang, Mao Tsun Lin, Pei Jarn Chen, Sheng Hsien Chen

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

摘要

Heatstroke is a form of excessive hyperthermia associated with a systemic inflammatory response that leads to multi-organ dysfunction in which central nervous system disorders predominate. Herein we determined to ascertain whether heat-induced multi-organ dysfunction in rats could be attenuated by granulocyte-colony stimulating factor (G-CSF) preconditioning. Anesthetized rats were divided into 2 major groups and given vehicle solution (isotonic saline, 0.3 ml, subcutaneously) or G-CSF (50-200 μg/kg body weight in 0.3 ml normal saline, subcutaneously) daily and consecutively for 5 days before the start of thermal experiments. They were exposed to an ambient temperature of 43 °C for 68 min to induce heatstroke. G-CSF preconditioning significantly prolonged the survival time in heatstroke rats in a dose-related way (82-98 min vs 127-243 min). The non-preconditioning heatstroke animals showed hyperthermia, arterial hypotension, increased serum levels of systemic inflammatory response molecules, increased hypothalamic apoptotic cell numbers as well as neuronal damage scores, and increased serum levels of renal and hepatic dysfunction indicators. These heatstroke syndromes could be significantly reduced by G-CSF preconditioning. Thus our results revealed a potential for G-CSF used as a prophylactic agent for heatstroke in rats.

原文英語
頁(從 - 到)109-117
頁數9
期刊European Journal of Pharmacology
661
發行號1-3
DOIs
出版狀態已發佈 - 七月 1 2011
對外發佈Yes

ASJC Scopus subject areas

  • Pharmacology

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  • 引用此

    Yung, M. C., Hsu, C. C., Kang, C. Y., Lin, C. L., Chang, S. L., Wang, J. J., Lin, M. T., Chen, P. J., & Chen, S. H. (2011). A potential for granulocyte-colony stimulating factor for use as a prophylactic agent for heatstroke in rats. European Journal of Pharmacology, 661(1-3), 109-117. https://doi.org/10.1016/j.ejphar.2011.04.018