TY - JOUR
T1 - A portable micro gas chromatography system for lung cancer associated volatile organic compound detection
AU - Tzeng, Te Hsuen
AU - Kuo, Chun Yen
AU - Wang, San Yuan
AU - Huang, Po Kai
AU - Huang, Yen Ming
AU - Hsieh, Wei Che
AU - Huang, Yu Jie
AU - Kuo, Po Hung
AU - Yu, Shih An
AU - Lee, Si Chen
AU - Tseng, Yufeng Jane
AU - Tian, Wei Cheng
AU - Lu, Shey Shi
PY - 2016/1/1
Y1 - 2016/1/1
N2 - With the help of micro-electromechanical systems (MEMS) and complementary metal-oxide-semiconductor (CMOS) technology, a portable micro gas chromatography (μGC) system for lung cancer associated volatile organic compounds (VOCs) detection is realized for the first time. The system is composed of an MEMS preconcentrator, an MEMS separation column, and a CMOS system-on-chip (SoC). The preconcentrator provides a concentration ratio of 2170. The separation column can separate more than seven types of lung cancer associated VOCs. The SoC is fabricated by a TSMC 0.35 μm 2P4M process including the CMOS VOCs detector, sensor calibration circuit, low-noise chopper instrumentation amplifier (IA), 10 bit analog to digital converter, and the microcontrol unit (MCU). Experimental results show that the system is able to detect seven types of lung cancer associated VOCs (acetone, 2-butanone, benzene, heptane, toluene, m-xylene, 1,3,5-trimethylbenzene). The concentration linearity is R2 = 0.985 and the detection sensitivity is up to 15 ppb with 1,3,5-trimethylbenzene.
AB - With the help of micro-electromechanical systems (MEMS) and complementary metal-oxide-semiconductor (CMOS) technology, a portable micro gas chromatography (μGC) system for lung cancer associated volatile organic compounds (VOCs) detection is realized for the first time. The system is composed of an MEMS preconcentrator, an MEMS separation column, and a CMOS system-on-chip (SoC). The preconcentrator provides a concentration ratio of 2170. The separation column can separate more than seven types of lung cancer associated VOCs. The SoC is fabricated by a TSMC 0.35 μm 2P4M process including the CMOS VOCs detector, sensor calibration circuit, low-noise chopper instrumentation amplifier (IA), 10 bit analog to digital converter, and the microcontrol unit (MCU). Experimental results show that the system is able to detect seven types of lung cancer associated VOCs (acetone, 2-butanone, benzene, heptane, toluene, m-xylene, 1,3,5-trimethylbenzene). The concentration linearity is R2 = 0.985 and the detection sensitivity is up to 15 ppb with 1,3,5-trimethylbenzene.
KW - Biomedical
KW - Calibration
KW - Complementary metal-oxide-semiconductor-micro-electromechanical system (CMOS-MEMS)
KW - Continuous wavelet transform (CWT)
KW - Deconvolution
KW - Micro gas chromatography (μGC )
KW - System-on-chip (SoC)
KW - Volatile organic compound (VOCS)
UR - http://www.scopus.com/inward/record.url?scp=84946763758&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946763758&partnerID=8YFLogxK
U2 - 10.1109/JSSC.2015.2489839
DO - 10.1109/JSSC.2015.2489839
M3 - Article
AN - SCOPUS:84946763758
SN - 0018-9200
VL - 51
SP - 259
EP - 272
JO - IEEE Journal of Solid-State Circuits
JF - IEEE Journal of Solid-State Circuits
IS - 1
M1 - 7314865
ER -
