A portable micro gas chromatography system for lung cancer associated volatile organic compound detection

Te Hsuen Tzeng, Chun Yen Kuo, San Yuan Wang, Po Kai Huang, Yen Ming Huang, Wei Che Hsieh, Yu Jie Huang, Po Hung Kuo, Shih An Yu, Si Chen Lee, Yufeng Jane Tseng, Wei Cheng Tian, Shey Shi Lu

研究成果: 雜誌貢獻文章

29 引文 (Scopus)

摘要

With the help of micro-electromechanical systems (MEMS) and complementary metal-oxide-semiconductor (CMOS) technology, a portable micro gas chromatography (μGC) system for lung cancer associated volatile organic compounds (VOCs) detection is realized for the first time. The system is composed of an MEMS preconcentrator, an MEMS separation column, and a CMOS system-on-chip (SoC). The preconcentrator provides a concentration ratio of 2170. The separation column can separate more than seven types of lung cancer associated VOCs. The SoC is fabricated by a TSMC 0.35 μm 2P4M process including the CMOS VOCs detector, sensor calibration circuit, low-noise chopper instrumentation amplifier (IA), 10 bit analog to digital converter, and the microcontrol unit (MCU). Experimental results show that the system is able to detect seven types of lung cancer associated VOCs (acetone, 2-butanone, benzene, heptane, toluene, m-xylene, 1,3,5-trimethylbenzene). The concentration linearity is R2 = 0.985 and the detection sensitivity is up to 15 ppb with 1,3,5-trimethylbenzene.
原文英語
文章編號7314865
頁(從 - 到)259-272
頁數14
期刊IEEE Journal of Solid-State Circuits
51
發行號1
DOIs
出版狀態已發佈 - 一月 1 2016
對外發佈Yes

指紋

Volatile organic compounds
Gas chromatography
MEMS
Metals
Heptane
Xylene
Digital to analog conversion
Acetone
Toluene
Benzene
Calibration
Detectors
Networks (circuits)
Sensors
Oxide semiconductors
System-on-chip

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

引用此文

A portable micro gas chromatography system for lung cancer associated volatile organic compound detection. / Tzeng, Te Hsuen; Kuo, Chun Yen; Wang, San Yuan; Huang, Po Kai; Huang, Yen Ming; Hsieh, Wei Che; Huang, Yu Jie; Kuo, Po Hung; Yu, Shih An; Lee, Si Chen; Tseng, Yufeng Jane; Tian, Wei Cheng; Lu, Shey Shi.

於: IEEE Journal of Solid-State Circuits, 卷 51, 編號 1, 7314865, 01.01.2016, p. 259-272.

研究成果: 雜誌貢獻文章

Tzeng, TH, Kuo, CY, Wang, SY, Huang, PK, Huang, YM, Hsieh, WC, Huang, YJ, Kuo, PH, Yu, SA, Lee, SC, Tseng, YJ, Tian, WC & Lu, SS 2016, 'A portable micro gas chromatography system for lung cancer associated volatile organic compound detection', IEEE Journal of Solid-State Circuits, 卷 51, 編號 1, 7314865, 頁 259-272. https://doi.org/10.1109/JSSC.2015.2489839
Tzeng, Te Hsuen ; Kuo, Chun Yen ; Wang, San Yuan ; Huang, Po Kai ; Huang, Yen Ming ; Hsieh, Wei Che ; Huang, Yu Jie ; Kuo, Po Hung ; Yu, Shih An ; Lee, Si Chen ; Tseng, Yufeng Jane ; Tian, Wei Cheng ; Lu, Shey Shi. / A portable micro gas chromatography system for lung cancer associated volatile organic compound detection. 於: IEEE Journal of Solid-State Circuits. 2016 ; 卷 51, 編號 1. 頁 259-272.
@article{ae81d67eaa654ae8a741b8580bc44828,
title = "A portable micro gas chromatography system for lung cancer associated volatile organic compound detection",
abstract = "With the help of micro-electromechanical systems (MEMS) and complementary metal-oxide-semiconductor (CMOS) technology, a portable micro gas chromatography (μGC) system for lung cancer associated volatile organic compounds (VOCs) detection is realized for the first time. The system is composed of an MEMS preconcentrator, an MEMS separation column, and a CMOS system-on-chip (SoC). The preconcentrator provides a concentration ratio of 2170. The separation column can separate more than seven types of lung cancer associated VOCs. The SoC is fabricated by a TSMC 0.35 μm 2P4M process including the CMOS VOCs detector, sensor calibration circuit, low-noise chopper instrumentation amplifier (IA), 10 bit analog to digital converter, and the microcontrol unit (MCU). Experimental results show that the system is able to detect seven types of lung cancer associated VOCs (acetone, 2-butanone, benzene, heptane, toluene, m-xylene, 1,3,5-trimethylbenzene). The concentration linearity is R2 = 0.985 and the detection sensitivity is up to 15 ppb with 1,3,5-trimethylbenzene.",
keywords = "Biomedical, Calibration, Complementary metal-oxide-semiconductor-micro-electromechanical system (CMOS-MEMS), Continuous wavelet transform (CWT), Deconvolution, Micro gas chromatography (μGC ), System-on-chip (SoC), Volatile organic compound (VOCS)",
author = "Tzeng, {Te Hsuen} and Kuo, {Chun Yen} and Wang, {San Yuan} and Huang, {Po Kai} and Huang, {Yen Ming} and Hsieh, {Wei Che} and Huang, {Yu Jie} and Kuo, {Po Hung} and Yu, {Shih An} and Lee, {Si Chen} and Tseng, {Yufeng Jane} and Tian, {Wei Cheng} and Lu, {Shey Shi}",
year = "2016",
month = "1",
day = "1",
doi = "10.1109/JSSC.2015.2489839",
language = "English",
volume = "51",
pages = "259--272",
journal = "IEEE Journal of Solid-State Circuits",
issn = "0018-9200",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
number = "1",

}

TY - JOUR

T1 - A portable micro gas chromatography system for lung cancer associated volatile organic compound detection

AU - Tzeng, Te Hsuen

AU - Kuo, Chun Yen

AU - Wang, San Yuan

AU - Huang, Po Kai

AU - Huang, Yen Ming

AU - Hsieh, Wei Che

AU - Huang, Yu Jie

AU - Kuo, Po Hung

AU - Yu, Shih An

AU - Lee, Si Chen

AU - Tseng, Yufeng Jane

AU - Tian, Wei Cheng

AU - Lu, Shey Shi

PY - 2016/1/1

Y1 - 2016/1/1

N2 - With the help of micro-electromechanical systems (MEMS) and complementary metal-oxide-semiconductor (CMOS) technology, a portable micro gas chromatography (μGC) system for lung cancer associated volatile organic compounds (VOCs) detection is realized for the first time. The system is composed of an MEMS preconcentrator, an MEMS separation column, and a CMOS system-on-chip (SoC). The preconcentrator provides a concentration ratio of 2170. The separation column can separate more than seven types of lung cancer associated VOCs. The SoC is fabricated by a TSMC 0.35 μm 2P4M process including the CMOS VOCs detector, sensor calibration circuit, low-noise chopper instrumentation amplifier (IA), 10 bit analog to digital converter, and the microcontrol unit (MCU). Experimental results show that the system is able to detect seven types of lung cancer associated VOCs (acetone, 2-butanone, benzene, heptane, toluene, m-xylene, 1,3,5-trimethylbenzene). The concentration linearity is R2 = 0.985 and the detection sensitivity is up to 15 ppb with 1,3,5-trimethylbenzene.

AB - With the help of micro-electromechanical systems (MEMS) and complementary metal-oxide-semiconductor (CMOS) technology, a portable micro gas chromatography (μGC) system for lung cancer associated volatile organic compounds (VOCs) detection is realized for the first time. The system is composed of an MEMS preconcentrator, an MEMS separation column, and a CMOS system-on-chip (SoC). The preconcentrator provides a concentration ratio of 2170. The separation column can separate more than seven types of lung cancer associated VOCs. The SoC is fabricated by a TSMC 0.35 μm 2P4M process including the CMOS VOCs detector, sensor calibration circuit, low-noise chopper instrumentation amplifier (IA), 10 bit analog to digital converter, and the microcontrol unit (MCU). Experimental results show that the system is able to detect seven types of lung cancer associated VOCs (acetone, 2-butanone, benzene, heptane, toluene, m-xylene, 1,3,5-trimethylbenzene). The concentration linearity is R2 = 0.985 and the detection sensitivity is up to 15 ppb with 1,3,5-trimethylbenzene.

KW - Biomedical

KW - Calibration

KW - Complementary metal-oxide-semiconductor-micro-electromechanical system (CMOS-MEMS)

KW - Continuous wavelet transform (CWT)

KW - Deconvolution

KW - Micro gas chromatography (μGC )

KW - System-on-chip (SoC)

KW - Volatile organic compound (VOCS)

UR - http://www.scopus.com/inward/record.url?scp=84946763758&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946763758&partnerID=8YFLogxK

U2 - 10.1109/JSSC.2015.2489839

DO - 10.1109/JSSC.2015.2489839

M3 - Article

AN - SCOPUS:84946763758

VL - 51

SP - 259

EP - 272

JO - IEEE Journal of Solid-State Circuits

JF - IEEE Journal of Solid-State Circuits

SN - 0018-9200

IS - 1

M1 - 7314865

ER -