A population-based cohort study suggests an increased risk of multiple sclerosis incidence in patients with type 2 diabetes mellitus

Wen Hsuan Hou, Chung Yi Li, Hsin-Hui Chang, Yu Sun, Chiang Chin Tsai

研究成果: 雜誌貢獻文章

5 引文 斯高帕斯(Scopus)

摘要

Background: To prospectively investigate the incidence and relative risks of multiple sclerosis (MS) in patients with type 2 diabetes (T2DM). Materials and methods: Patients with T2DM (n = 614,623) and age- and sex-matched controls (n = 614,021) were followed from 2000 to 2008 to identify cases of newly diagnosed MS (ICD-9-CM: 340). The person-year approach with Poisson assumption was used to evaluate the incidence density. We estimated the covariate-adjusted hazard ratio (HR) of MS incidence in relation to T2DM diabetes using a multiple Cox proportional hazard regression model. Results: Over 9 years of follow-up, 175 T2DM patients were newly diagnosed with MS, and 114 matched controls had the same first-ever diagnosis, representing a covariate-adjusted HR of 1.44 (95% confidence interval [CI], 1.08-1.94). The sex-specific adjusted HR for both men and women with T2DM was also elevated at 1.34 (95% CI, 0.81-2.23) and 1.51 (95% CI, 1.05-2.19), respectively. Women aged <50 years had the greatest risk of MS (HR 2.16; 95% CI, 1.02-4.59). Conclusion: This study demonstrated a moderate but significant association of T2DM with MS incidence, and the association was not confounded by socio-demographic characteristics or certain MS-related comorbidities.
原文英語
頁(從 - 到)235-241
頁數7
期刊Journal of Epidemiology
27
發行號5
DOIs
出版狀態已發佈 - 2017

    指紋

ASJC Scopus subject areas

  • Epidemiology

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