A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis

Jeng Hsien Yen, Che Mai Chang, Yu Wen Hsu, Chih Hung Lee, Mei Shin Wu, Daw Yang Hwang, Ben Kuen Chen, Hsien Tzung Liao, Man Tzu Marcie Wu, Wei Chiao Chang

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)

摘要

Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune diseases. To identify whether ORAI1 gene contributes to RA susceptibility, we enrolled 400 patients with RA and 621 healthy individuals for a case-control genetic association study. Five tagging single nucleotides polymorphisms (tSPNs) within ORAI1 gene were selected for genotyping. An SNP, rs7135617, showed a significant correlation with the risk of RA. Our results indicated that genetic polymorphism of ORAI1 gene is involved in the susceptibility of RA in a Taiwanese population.

原文英語
文章編號834831
期刊Mediators of Inflammation
2014
DOIs
出版狀態已發佈 - 2014

    指紋

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Medicine(all)

引用此

Yen, J. H., Chang, C. M., Hsu, Y. W., Lee, C. H., Wu, M. S., Hwang, D. Y., Chen, B. K., Liao, H. T., Wu, M. T. M., & Chang, W. C. (2014). A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis. Mediators of Inflammation, 2014, [834831]. https://doi.org/10.1155/2014/834831