19 引文 斯高帕斯(Scopus)

摘要

Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune diseases. To identify whether ORAI1 gene contributes to RA susceptibility, we enrolled 400 patients with RA and 621 healthy individuals for a case-control genetic association study. Five tagging single nucleotides polymorphisms (tSPNs) within ORAI1 gene were selected for genotyping. An SNP, rs7135617, showed a significant correlation with the risk of RA. Our results indicated that genetic polymorphism of ORAI1 gene is involved in the susceptibility of RA in a Taiwanese population.

原文英語
文章編號834831
期刊Mediators of Inflammation
2014
DOIs
出版狀態已發佈 - 2014

ASJC Scopus subject areas

  • 免疫學
  • 細胞生物學

指紋

深入研究「A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis」主題。共同形成了獨特的指紋。

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