A pasteurized therapeutic plasma

M. Burnouf-Radosevich, T. Burnouf, J. J. Huart

研究成果: 雜誌貢獻文章同行評審

27 引文 斯高帕斯(Scopus)

摘要

A process to subject pooled human plasma to a viral inactivation treatment by heating in the liquid state for 10 hrs at 60°C (pasteurization) has been designed and evaluated. Activity recovered from clotting factors and protease inhibitors exceeded 80%. Overall clotting activity remained good. No activation of coagulation factors was detected. The process did not generate aggregates. No side effects (toxicity. hypotension, variation in heart rate, thrombogenicity) could be detected in animal models. Virus kill studies, using 7 lipid-enveloped and non-enveloped viruses including HIV-1 and Sindbis virus, revealed inactivation levels similar to those obtained for plasma derivatives. Thus, pasteurisation of human plasma can be achieved in conditions that allow good recovery of biological properties while ensuring a high degree of inactivation of lipid-enveloped and non-enveloped viruses.
原文英語
頁(從 - 到)91-94
頁數4
期刊Transfusion Medicine and Hemotherapy
19
發行號2
DOIs
出版狀態已發佈 - 1992
對外發佈

ASJC Scopus subject areas

  • 血液學
  • 免疫學和過敏

指紋

深入研究「A pasteurized therapeutic plasma」主題。共同形成了獨特的指紋。

引用此