摘要
原文 | 英語 |
---|---|
頁(從 - 到) | 1409-1415 |
頁數 | 7 |
期刊 | ACS Sensors |
卷 | 3 |
發行號 | 7 |
DOIs | |
出版狀態 | 已發佈 - 七月 27 2018 |
指紋
ASJC Scopus subject areas
- Bioengineering
- Instrumentation
- Process Chemistry and Technology
- Fluid Flow and Transfer Processes
引用此文
A Novel Thermal Bubble Valve Integrated Nanofluidic Preconcentrator for Highly Sensitive Biomarker Detection. / Deng, Chih Zong; Fan, Yu Jui; Chung, Pei Shan; Sheen, Horn Jiunn.
於: ACS Sensors, 卷 3, 編號 7, 27.07.2018, p. 1409-1415.研究成果: 雜誌貢獻 › 文章
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TY - JOUR
T1 - A Novel Thermal Bubble Valve Integrated Nanofluidic Preconcentrator for Highly Sensitive Biomarker Detection
AU - Deng, Chih Zong
AU - Fan, Yu Jui
AU - Chung, Pei Shan
AU - Sheen, Horn Jiunn
PY - 2018/7/27
Y1 - 2018/7/27
N2 - In this study, we developed a new immunosensor that can achieve an ultralow detection limit and high sensitivity. This new device has an electrokinetic trapping (EKT)-based nanofluidic preconcentrator, which was integrated with oscillating bubble valves, to trap concentrated antigen and immunobeads. During the immunoassay process, oscillating bubbles rapidly grew and acted as control valves and to block the microchannel. Thereafter, the trapped preconcentrated antigen plug and antibody-coated nanobeads were preserved in the region between these two valves. Finally, the antigen concentration was quantitatively analyzed by a real-time measurement of Brownian diffusion of the immunobeads. In this work, the test sample used was C-reactive protein (CRP) which is a risk indicator of coronary heart disease and atherosclerosis.
AB - In this study, we developed a new immunosensor that can achieve an ultralow detection limit and high sensitivity. This new device has an electrokinetic trapping (EKT)-based nanofluidic preconcentrator, which was integrated with oscillating bubble valves, to trap concentrated antigen and immunobeads. During the immunoassay process, oscillating bubbles rapidly grew and acted as control valves and to block the microchannel. Thereafter, the trapped preconcentrated antigen plug and antibody-coated nanobeads were preserved in the region between these two valves. Finally, the antigen concentration was quantitatively analyzed by a real-time measurement of Brownian diffusion of the immunobeads. In this work, the test sample used was C-reactive protein (CRP) which is a risk indicator of coronary heart disease and atherosclerosis.
KW - acoustic wave
KW - Brownian motion
KW - C-reactive protein
KW - immunobeads
KW - nanofluidic preconcentrator
KW - oscillating thermal microbubble
UR - http://www.scopus.com/inward/record.url?scp=85048512121&partnerID=8YFLogxK
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U2 - 10.1021/acssensors.8b00323
DO - 10.1021/acssensors.8b00323
M3 - Article
AN - SCOPUS:85048512121
VL - 3
SP - 1409
EP - 1415
JO - ACS Sensors
JF - ACS Sensors
SN - 2379-3694
IS - 7
ER -