A novel single nucleotide polymorphism in XRCC4 gene is associated with gastric cancer susceptibility in Taiwan

Chang Fang Chiu, Chung Hsing Wang, Cheng Li Wang, Cheng Chieh Lin, Nan Yung Hsu, Jing Ru Weng, Da Tian Bau

研究成果: 雜誌貢獻文章同行評審

69 引文 斯高帕斯(Scopus)

摘要

Background: The DNA repair gene XRCC4, an important caretaker of the overall genome stability, is thought to play a major role in the human carcinogenesis. We investigate some novel and important polymorphic variants of XRCC4, at codon 247 (rs3734091), G-1394T (rs6869366), intron 3 (rs28360071), and intron 7 (rs28360317), of their associated with gastric cancer susceptibility. Materials and Methods: In this hospital-based case-control study, the association of XRCC4 polymorphisms with gastric cancer risk in a Taiwanese population was investigated. In total, 121 patients with gastric cancer and 121 age-matched healthy controls recruited were genotyped investigating these polymorphisms' association with gastric cancer susceptibility. Results: We found a significant difference in the frequency of the XRCC4 G-1394T genotype, but not others, between the gastric cancer and control groups. Those who had G/T or G/G at XRCC4 G-1394T showed a 3.79-fold (95% confidence interval = 1.47-9.82) increased risk of gastric cancer compared to those with T/T. As for XRCC4 codon 247, intron 3, or intron 7, there was no difference in distribution between the gastric cancer and control groups. Conclusions: Our findings suggest that the G allele of the XRCC4 G-1394T may contribute to gastric carcinogenesis and may be useful for gastric cancer early detection and prevention.
原文英語
頁(從 - 到)514-518
頁數5
期刊Annals of Surgical Oncology
15
發行號2
DOIs
出版狀態已發佈 - 二月 2008
對外發佈

ASJC Scopus subject areas

  • 手術
  • 腫瘤科

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