A novel rotating electrochemically anodizing process to fabricate titanium oxide surface nanostructures enhancing the bioactivity of osteoblastic cells

Chih Hung Chang, Hsin Chun Lee, Chia Chun Chen, Yi Hau Wu, Yuan Ming Hsu, Yin Pen Chang, Ta I. Yang, Hsu Wei Fang

研究成果: 雜誌貢獻文章同行評審

12 引文 斯高帕斯(Scopus)

摘要

Titanium oxide (TiO 2) surface layers with various surface nanostructures (nanotubes and nanowires) have been developed using an anodizing technique. The pore size and length of TiO 2 nanotubes can be tailored by changing the anodizing time and applied voltage. We developed a novel method to transform the upper part of the formed TiO 2 nanotubes into a nanowire-like structure by rotating the titanium anode during anodizing process. The transformation of nanotubes contributed to the preferential chemical dissolution of TiO 2 on the areas with intense interface tension stress. Furthermore, we further compared the effect of various TiO 2 surface nanostructures including flat, nanotubes, and nanowires on bioactive applications. The MG-63 osteoblastic cells cultured on the TiO 2 nanowires exhibited a polygonal shape with extending filopodia and showed highest levels of cell viability and alkaline phosphatase activity (ALP). The TiO 2 nanowire structure formed by our novel method can provide beneficial effects for MG-63 osteoblastic cells in attachment, proliferation, and secretion of ALP on the TiO 2 surface layer.
原文英語
頁(從 - 到)1687-1695
頁數9
期刊Journal of Biomedical Materials Research - Part A
100 A
發行號7
DOIs
出版狀態已發佈 - 七月 1 2012
對外發佈

ASJC Scopus subject areas

  • 陶瓷和複合材料
  • 生物材料
  • 生物醫學工程
  • 金屬和合金

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