A novel mechanism involved in TLR4 expression during inflammation

Chi Yuan Li, Feng Yen Lin

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

The p47phox- and Rac1-dependent NADPH oxidase activation, ROS production, and MAPK signaling pathways play critical roles in endotoxin-enhanced TLR4 expression and TLR4 mRNA stabilization in VSMCs. These evidences provide for the direct involvement of VSMCs in endotoxin-mediated inflammatory activation, which may contribute to the progression of cardiovascular disorders, although targeting TLR4 will prove to be a successful approach for the treatment of these devastating diseases remains to be determined.

原文英語
頁(從 - 到)63-64
頁數2
期刊Acta Anaesthesiologica Taiwanica
45
發行號2
出版狀態已發佈 - 六月 2007
對外發佈Yes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Medicine(all)

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