A novel HLA-B allele, B*58: 01:12, detected in a Taiwanese volunteer bone marrow stem cell donor using sequence-based typing method

K. L. Yang, S. K. Lee, R. H. Kao, C. L. Lin, P. Y. Lin

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

摘要

Human leukocyte antigen-B*58:01:12, a novel rare allele of HLA-B*58:01 variant, was found in a Taiwanese volunteer bone marrow donor by SBT (sequence-based typing) method. The DNA sequence of B*58:01:12 is identical to the sequence of B*58:01:01 in exons 2, 3 and 4 except at nucleotide position 483 where nucleotide C is substituted by T (at codon 137; GAC GAT). Due to the silent point mutation, the amino acid sequence of B*58:01:12 is identical to the sequence of B*58:01:01. The HLA haplotype in association with B*58:01:12 may be deduced as A*33:03-B*58:01:12-DRB1*03:01. The discovery of B*58:01:12 adds further polymorphism of B*58:01 in Taiwanese population.
原文英語
頁(從 - 到)324-325
頁數2
期刊International Journal of Immunogenetics
40
發行號4
DOIs
出版狀態已發佈 - 八月 1 2013
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Immunology
  • Genetics(clinical)
  • Medicine(all)

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