A novel HLA-B allele, B*58

01:12, detected in a Taiwanese volunteer bone marrow stem cell donor using sequence-based typing method

K. L. Yang, S. K. Lee, R. H. Kao, C. L. Lin, P. Y. Lin

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

Human leukocyte antigen-B*58:01:12, a novel rare allele of HLA-B*58:01 variant, was found in a Taiwanese volunteer bone marrow donor by SBT (sequence-based typing) method. The DNA sequence of B*58:01:12 is identical to the sequence of B*58:01:01 in exons 2, 3 and 4 except at nucleotide position 483 where nucleotide C is substituted by T (at codon 137; GAC GAT). Due to the silent point mutation, the amino acid sequence of B*58:01:12 is identical to the sequence of B*58:01:01. The HLA haplotype in association with B*58:01:12 may be deduced as A*33:03-B*58:01:12-DRB1*03:01. The discovery of B*58:01:12 adds further polymorphism of B*58:01 in Taiwanese population.
原文英語
頁(從 - 到)324-325
頁數2
期刊International Journal of Immunogenetics
40
發行號4
DOIs
出版狀態已發佈 - 八月 1 2013
對外發佈Yes

指紋

HLA-B Antigens
Bone Marrow Cells
Volunteers
Stem Cells
Nucleotides
Alleles
Tissue Donors
HLA Antigens
Point Mutation
Codon
Haplotypes
Amino Acid Sequence
Exons
Bone Marrow
Population
Silent Mutation
GAT

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Immunology
  • Genetics(clinical)
  • Medicine(all)

引用此文

A novel HLA-B allele, B*58 : 01:12, detected in a Taiwanese volunteer bone marrow stem cell donor using sequence-based typing method. / Yang, K. L.; Lee, S. K.; Kao, R. H.; Lin, C. L.; Lin, P. Y.

於: International Journal of Immunogenetics, 卷 40, 編號 4, 01.08.2013, p. 324-325.

研究成果: 雜誌貢獻文章

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abstract = "Human leukocyte antigen-B*58:01:12, a novel rare allele of HLA-B*58:01 variant, was found in a Taiwanese volunteer bone marrow donor by SBT (sequence-based typing) method. The DNA sequence of B*58:01:12 is identical to the sequence of B*58:01:01 in exons 2, 3 and 4 except at nucleotide position 483 where nucleotide C is substituted by T (at codon 137; GAC GAT). Due to the silent point mutation, the amino acid sequence of B*58:01:12 is identical to the sequence of B*58:01:01. The HLA haplotype in association with B*58:01:12 may be deduced as A*33:03-B*58:01:12-DRB1*03:01. The discovery of B*58:01:12 adds further polymorphism of B*58:01 in Taiwanese population.",
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