A novel HA/β-TCP-collagen composite enhanced new bone formation for dental extraction socket preservation in beagle dogs

Ko Ning Ho, Eisner Salamanca, Kuo Chi Chang, Tsai Chin Shih, Yu Chi Chang, Haw Ming Huang, Nai Chia Teng, Che Tong Lin, Sheng-Wei Feng, Wei Jen Chang

研究成果: 雜誌貢獻文章

9 引文 斯高帕斯(Scopus)

摘要

Past studies in humans have demonstrated horizontal and vertical bone loss after six months following tooth extraction. Many biomaterials have been developed to preserve bone volume after tooth extraction. Type I collagen serves as an excellent delivery system for growth factors and promotes angiogenesis. Calcium phosphate ceramics have also been investigated because their mineral chemistry resembles human bone. The aim of this study was to compare the performance of a novel bioresorbable purified fibrillar collagen and hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) ceramic composite versus collagen alone and a bovine xenograft-collagen composite in beagles. Collagen plugs, bovine graft-collagen composite and HA/β-TCP-collagen composite were implanted into the left and right first, second and third mandibular premolars, and the fourth molar was left empty for natural healing. In total, 20 male beagle dogs were used, and quantitative and histological analyses of the extraction ridge was done. The smallest width reduction was 19.09% ± 8.81% with the HA/β-TCP-collagen composite at Week 8, accompanied by new bone formation at Weeks 4 and 8. The HA/β-TCP-collagen composite performed well, as a new osteoconductive and biomimetic composite biomaterial, for socket bone preservation after tooth extraction.
原文英語
文章編號191
期刊Materials
9
發行號3
DOIs
出版狀態已發佈 - 三月 11 2016

ASJC Scopus subject areas

  • Materials Science(all)

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