A novel global strain diastolic index correlates with plasma NT-proBNP levels in asymptomatic hypertensive patients with preserved left ventricular ejection fraction

Shuo Ju Chiang, Masao Daimon, Katsuhisa Ishii, Sakiko Miyazaki, Yoko Koiso, Hiromasa Suzuki, Katsumi Miyauchi, Bei Yang, Mei Hsiu Yeh, Betau Hwang, Hiroyuki Daida

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1 引文 斯高帕斯(Scopus)

摘要

Background: The strain imaging diastolic index (SI-DI) was reported to be a sensitive marker of regional left ventricular (LV) delayed relaxation induced by ischemia. However, the clinical usefulness of the global SI-DI has not been evaluated. N-terminal pro-brain natriuretic peptide (NT-proBNP) is a sensitive biomarker for the detection of asymptomatic diastolic LV dysfunction. This study investigated the ability of a novel parameter, the global SI-DI, obtained using 2D speckle tracking imaging (2DSI) to correlate with the plasma NT-proBNP levels in asymptomatic hypertensive patients with preserved LV ejection fraction. Methods: We performed 2D echocardiography and 2DSI in 83 asymptomatic hypertensive patients with preserved ejection fraction (>45 %) and in 37 control subjects. In 2DSI, the LV longitudinal peak strain and the SI-DI of 18 LV segments were measured. NT-proBNP was measured in all subjects. The data were compared between hypertensive patients and normal controls. Results: The average peak strain and global SI-DI of 18 LV segments were significantly reduced in hypertensive patients compared with control subjects (P <0.05); however, only the global SI-DI was significantly correlated with log 10 NT-proBNP (r = -0.469, P = 0.001). In Pearson's correlation analyses, log 10 NT-proBNP was significantly correlated with E/e′, E/A ratio, early diastolic mitral annular velocity (e′), global peak strain, deceleration time of the E-wave, and LV ejection fraction. In the multiple stepwise regression analysis, the global SI-DI was the strongest independent determinant of log 10 NT-proBNP (β = -0.386, P = 0.008). Conclusions: The global SI-DI derived from 2DSI correlates well with plasma NT-proBNP levels and may have prognostic value in asymptomatic hypertensive patients with preserved ejection fraction.

原文英語
頁(從 - 到)56-64
頁數9
期刊Journal of Echocardiography
10
發行號2
DOIs
出版狀態已發佈 - 6月 2012
對外發佈

ASJC Scopus subject areas

  • 放射學、核子醫學和影像學

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