A novel DNA structure induced by the anticancer bisplatinum compound crosslinked to a GpC site in DNA

Danzhou Yang, Stella S.G.E. van Boom, Jan Reedijk, Jacques H. van Boom, Nicholas Farrell, Andrew H.J. Wang

研究成果: 雜誌貢獻文章同行評審

66 引文 斯高帕斯(Scopus)

摘要

The bifunctional platinum compound, [{trans-PtCI(NH3)2}2(H2N(CH2)4NH2)]2+f forms a stable adduct with the self-complementary DNA oligomer CATGCATG, with the two platinum atoms coordinated at the N7 positions of the two symmetrical G4 nucleotides. The NMR-derived structure shows that the DNA octamer forms a novel hairpin structure with the platinated G4 residue adopting a syn conformation and the guanine base in the minor groove. Two such hairpins stack end-over-end and are linked together by the butanediamine tether to form a dumbbell structure. Such unusual structural distortion is different from that of the anticancer drug cisplatin-DNA adduct and may provide clues to explain the distinct biological activities of the two compounds.

原文英語
頁(從 - 到)577-586
頁數10
期刊Nature Structural Biology
2
發行號7
DOIs
出版狀態已發佈 - 7月 1995
對外發佈

ASJC Scopus subject areas

  • 結構生物學
  • 生物化學
  • 遺傳學

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