A novel approach for prediction of multi-labeled protein subcellular localization for prokaryotic bacteria

Chia Yu Su, Allan Lo, Chin Chin Lin, Fu Chang, Wen Lian Hsu

研究成果: 書貢獻/報告類型會議貢獻

6 引文 斯高帕斯(Scopus)

摘要

We present a novel method to address multi-labeled protein subcellular localization prediction in Gram-negative bacteria using support vector machines (SVM) as classifiers. For a given protein sequence that may have more than one label, features are extracted from amino acid composition and molecular function related terms in Gene Ontology (GO) as input to SVM. We apply one-against-others SVM to proteins of Gram-negative bacteria in a 5-fold cross-validation. The results of the multi-labeled predictions are evaluated based on two criteria: class number and class category. For the first criterion, our method predicts the number of classes (class number) for each protein at an accuracy rate of 94.1%. For the second criterion, we compare the categories of the actual classes with the predicted classes proportionate to ranks, and obtain an accuracy of 83.2%. Our method is the first approach to predict and evaluate multi-labeled protein subcellular localization for prokaryotic bacteria and we demonstrate that it has a good predictive power.
原文英語
主出版物標題2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts
頁面79-80
頁數2
DOIs
出版狀態已發佈 - 2005
對外發佈Yes
事件2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts - Stanford, CA, 美国
持續時間: 八月 8 2005八月 11 2005

其他

其他2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts
國家美国
城市Stanford, CA
期間8/8/058/11/05

ASJC Scopus subject areas

  • Engineering(all)

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  • 引用此

    Su, C. Y., Lo, A., Lin, C. C., Chang, F., & Hsu, W. L. (2005). A novel approach for prediction of multi-labeled protein subcellular localization for prokaryotic bacteria. 於 2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts (頁 79-80). [1540549] https://doi.org/10.1109/CSBW.2005.11