摘要
Objective: Papanicolaou (Pap) smear test is implemented to detect cervical intraepithelial neoplasia (CIN) in Taiwan. However, the utility of that has limitations. High-risk human papillomavirus (HR-HPV) is an important risk factor in development of cervical cancer. In this study, we estimate the utility of HR-HPV testing in the screening of CIN. Methods: Firstly, 726 subjects were recruited and willing to prove cervical exfoliated epithelial cells for Pap smear screening and HR-HPV DNA testing. Subsequently, 205 of the eligible subjects with greater than or equal to CIN1 of Pap smear results were asked to perform histologic diagnosis that served as a gold standard for the estimation of the effects of both Pap smear and HR-HPV testing. Results: The histology is significantly associated with HR-HPV infection, as well as significantly highly correlated with the individuals who have both Pap smear greater than or equal to CIN1 and positive HR-HPV infection but not significantly correlated with the individuals who only have Pap smear greater than or equal to CIN1 but without HR-HPV infection. Conclusions: Combinative surveillance of HR-HPV infection and Pap smear is a useful tool to detect and monitor precancerous lesions in the screening program. HR-HPV testing is a notable accessory screening program for detection of CIN in Taiwanese women.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 477-482 |
| 頁數 | 6 |
| 期刊 | Pathologie Biologie |
| 卷 | 57 |
| 發行號 | 6 |
| DOIs | |
| 出版狀態 | 已發佈 - 九月 2009 |
指紋
ASJC Scopus subject areas
- Pathology and Forensic Medicine
引用此文
A notable accessory screening program for detection of cervical intraepithelial neoplasia. / Tsai, H. T.; Tsai, Y. M.; Yang, S. F.; Lee, C. H.; Lin, L. Y.; Lee, S.; Wu, M. T.
於: Pathologie Biologie, 卷 57, 編號 6, 09.2009, p. 477-482.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - A notable accessory screening program for detection of cervical intraepithelial neoplasia
AU - Tsai, H. T.
AU - Tsai, Y. M.
AU - Yang, S. F.
AU - Lee, C. H.
AU - Lin, L. Y.
AU - Lee, S.
AU - Wu, M. T.
PY - 2009/9
Y1 - 2009/9
N2 - Objective: Papanicolaou (Pap) smear test is implemented to detect cervical intraepithelial neoplasia (CIN) in Taiwan. However, the utility of that has limitations. High-risk human papillomavirus (HR-HPV) is an important risk factor in development of cervical cancer. In this study, we estimate the utility of HR-HPV testing in the screening of CIN. Methods: Firstly, 726 subjects were recruited and willing to prove cervical exfoliated epithelial cells for Pap smear screening and HR-HPV DNA testing. Subsequently, 205 of the eligible subjects with greater than or equal to CIN1 of Pap smear results were asked to perform histologic diagnosis that served as a gold standard for the estimation of the effects of both Pap smear and HR-HPV testing. Results: The histology is significantly associated with HR-HPV infection, as well as significantly highly correlated with the individuals who have both Pap smear greater than or equal to CIN1 and positive HR-HPV infection but not significantly correlated with the individuals who only have Pap smear greater than or equal to CIN1 but without HR-HPV infection. Conclusions: Combinative surveillance of HR-HPV infection and Pap smear is a useful tool to detect and monitor precancerous lesions in the screening program. HR-HPV testing is a notable accessory screening program for detection of CIN in Taiwanese women.
AB - Objective: Papanicolaou (Pap) smear test is implemented to detect cervical intraepithelial neoplasia (CIN) in Taiwan. However, the utility of that has limitations. High-risk human papillomavirus (HR-HPV) is an important risk factor in development of cervical cancer. In this study, we estimate the utility of HR-HPV testing in the screening of CIN. Methods: Firstly, 726 subjects were recruited and willing to prove cervical exfoliated epithelial cells for Pap smear screening and HR-HPV DNA testing. Subsequently, 205 of the eligible subjects with greater than or equal to CIN1 of Pap smear results were asked to perform histologic diagnosis that served as a gold standard for the estimation of the effects of both Pap smear and HR-HPV testing. Results: The histology is significantly associated with HR-HPV infection, as well as significantly highly correlated with the individuals who have both Pap smear greater than or equal to CIN1 and positive HR-HPV infection but not significantly correlated with the individuals who only have Pap smear greater than or equal to CIN1 but without HR-HPV infection. Conclusions: Combinative surveillance of HR-HPV infection and Pap smear is a useful tool to detect and monitor precancerous lesions in the screening program. HR-HPV testing is a notable accessory screening program for detection of CIN in Taiwanese women.
KW - Cervical intraepithelial neoplasia (CIN)
KW - High-risk human papillomavirus (HR-HPV)
KW - Hybrid Capture II (HCII)
KW - Papanicolaou (Pap) smear
UR - http://www.scopus.com/inward/record.url?scp=69649086264&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69649086264&partnerID=8YFLogxK
U2 - 10.1016/j.patbio.2008.05.006
DO - 10.1016/j.patbio.2008.05.006
M3 - Article
C2 - 18586410
AN - SCOPUS:69649086264
VL - 57
SP - 477
EP - 482
JO - Current Research in Translational Medicine
JF - Current Research in Translational Medicine
SN - 2452-3186
IS - 6
ER -