A notable accessory screening program for detection of cervical intraepithelial neoplasia

H. T. Tsai, Y. M. Tsai, S. F. Yang, C. H. Lee, L. Y. Lin, S. Lee, M. T. Wu

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

Objective: Papanicolaou (Pap) smear test is implemented to detect cervical intraepithelial neoplasia (CIN) in Taiwan. However, the utility of that has limitations. High-risk human papillomavirus (HR-HPV) is an important risk factor in development of cervical cancer. In this study, we estimate the utility of HR-HPV testing in the screening of CIN. Methods: Firstly, 726 subjects were recruited and willing to prove cervical exfoliated epithelial cells for Pap smear screening and HR-HPV DNA testing. Subsequently, 205 of the eligible subjects with greater than or equal to CIN1 of Pap smear results were asked to perform histologic diagnosis that served as a gold standard for the estimation of the effects of both Pap smear and HR-HPV testing. Results: The histology is significantly associated with HR-HPV infection, as well as significantly highly correlated with the individuals who have both Pap smear greater than or equal to CIN1 and positive HR-HPV infection but not significantly correlated with the individuals who only have Pap smear greater than or equal to CIN1 but without HR-HPV infection. Conclusions: Combinative surveillance of HR-HPV infection and Pap smear is a useful tool to detect and monitor precancerous lesions in the screening program. HR-HPV testing is a notable accessory screening program for detection of CIN in Taiwanese women.

原文英語
頁(從 - 到)477-482
頁數6
期刊Pathologie Biologie
57
發行號6
DOIs
出版狀態已發佈 - 九月 2009

指紋

Cervical Intraepithelial Neoplasia
Papanicolaou Test
Accessories
Screening
Papillomavirus Infections
Testing
Histology
Taiwan
Uterine Cervical Neoplasms
Epithelial Cells
DNA

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

引用此文

A notable accessory screening program for detection of cervical intraepithelial neoplasia. / Tsai, H. T.; Tsai, Y. M.; Yang, S. F.; Lee, C. H.; Lin, L. Y.; Lee, S.; Wu, M. T.

於: Pathologie Biologie, 卷 57, 編號 6, 09.2009, p. 477-482.

研究成果: 雜誌貢獻文章

Tsai, H. T. ; Tsai, Y. M. ; Yang, S. F. ; Lee, C. H. ; Lin, L. Y. ; Lee, S. ; Wu, M. T. / A notable accessory screening program for detection of cervical intraepithelial neoplasia. 於: Pathologie Biologie. 2009 ; 卷 57, 編號 6. 頁 477-482.
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abstract = "Objective: Papanicolaou (Pap) smear test is implemented to detect cervical intraepithelial neoplasia (CIN) in Taiwan. However, the utility of that has limitations. High-risk human papillomavirus (HR-HPV) is an important risk factor in development of cervical cancer. In this study, we estimate the utility of HR-HPV testing in the screening of CIN. Methods: Firstly, 726 subjects were recruited and willing to prove cervical exfoliated epithelial cells for Pap smear screening and HR-HPV DNA testing. Subsequently, 205 of the eligible subjects with greater than or equal to CIN1 of Pap smear results were asked to perform histologic diagnosis that served as a gold standard for the estimation of the effects of both Pap smear and HR-HPV testing. Results: The histology is significantly associated with HR-HPV infection, as well as significantly highly correlated with the individuals who have both Pap smear greater than or equal to CIN1 and positive HR-HPV infection but not significantly correlated with the individuals who only have Pap smear greater than or equal to CIN1 but without HR-HPV infection. Conclusions: Combinative surveillance of HR-HPV infection and Pap smear is a useful tool to detect and monitor precancerous lesions in the screening program. HR-HPV testing is a notable accessory screening program for detection of CIN in Taiwanese women.",
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AB - Objective: Papanicolaou (Pap) smear test is implemented to detect cervical intraepithelial neoplasia (CIN) in Taiwan. However, the utility of that has limitations. High-risk human papillomavirus (HR-HPV) is an important risk factor in development of cervical cancer. In this study, we estimate the utility of HR-HPV testing in the screening of CIN. Methods: Firstly, 726 subjects were recruited and willing to prove cervical exfoliated epithelial cells for Pap smear screening and HR-HPV DNA testing. Subsequently, 205 of the eligible subjects with greater than or equal to CIN1 of Pap smear results were asked to perform histologic diagnosis that served as a gold standard for the estimation of the effects of both Pap smear and HR-HPV testing. Results: The histology is significantly associated with HR-HPV infection, as well as significantly highly correlated with the individuals who have both Pap smear greater than or equal to CIN1 and positive HR-HPV infection but not significantly correlated with the individuals who only have Pap smear greater than or equal to CIN1 but without HR-HPV infection. Conclusions: Combinative surveillance of HR-HPV infection and Pap smear is a useful tool to detect and monitor precancerous lesions in the screening program. HR-HPV testing is a notable accessory screening program for detection of CIN in Taiwanese women.

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