A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata

Zong-Huei Li, Ching Kuo Lee, Wan Lin Tsou, Sheng Yung Liu, Mao Tien Kuo, Wu Che Wen

研究成果: 雜誌貢獻文章

71 引文 (Scopus)

摘要

Antroquinonol (1), an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata (Polyporaceae, Aphyllophorales), a parasitic fungus indigenous to Taiwan. The structure of compound 1 was elucidated by the analysis of their spectroscopic data. Its cytotoxic activities were evaluated against MCF-7, MDA-MB-231 (human breast carcinoma), Hep3B, HepG2 (human liver carcinoma) and DU-145, LNCaP (human prostate carcinoma) cell lines, and the IC50 values ranged from 0.13 ± 0.02 to 6.09 ± 0.07 μM.

原文英語
頁(從 - 到)1412-1415
頁數4
期刊Planta Medica
73
發行號13
DOIs
出版狀態已發佈 - 十月 2007

指紋

Antrodia
Taiwanofungus camphoratus
Ubiquinone
Mycelium
Cytotoxins
Fungi
Liver
mycelium
Cells
Derivatives
Polyporaceae
Polyporales
Carcinoma
ubiquinones
prostatic neoplasms
Taiwan
breast neoplasms
Inhibitory Concentration 50
carcinoma
inhibitory concentration 50

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

引用此文

A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata. / Li, Zong-Huei; Lee, Ching Kuo; Tsou, Wan Lin; Liu, Sheng Yung; Kuo, Mao Tien; Wen, Wu Che.

於: Planta Medica, 卷 73, 編號 13, 10.2007, p. 1412-1415.

研究成果: 雜誌貢獻文章

Li, Zong-Huei ; Lee, Ching Kuo ; Tsou, Wan Lin ; Liu, Sheng Yung ; Kuo, Mao Tien ; Wen, Wu Che. / A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata. 於: Planta Medica. 2007 ; 卷 73, 編號 13. 頁 1412-1415.
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