A New Approach to Enhancement of Bone Formation by Electrically Polarized Hydroxyapatite

N. C. Teng, S. Nakamura, Y. Takagi, Y. Yamashita, M. Ohgaki, K. Yamashita

研究成果: 雜誌貢獻文章同行評審

80 引文 斯高帕斯(Scopus)

摘要

An electrical field may affect osteogenesis. Since we found that hydroxyapatite (HA) ceramics may be polarizable, we hypothesized that electrically polarized HA may foster production of new bone in vivo. Both polarized and non-polarized HA ceramics were inserted into the subperiosteum spaces at the parietal bone area of rats. After 2, 4, and 8 weeks, the implant sites were examined histologically. Morphometric analysis revealed that new bone formation was accelerated on the negatively charged surface of the polarized HA (N-surface) at 2 weeks. The newly formed bone approached maturation at 4 weeks and was thicker on the N-surface than in the controls. By 8 weeks, newly formed bone in the controls was almost the same as that on the N-surface. These findings suggest that polarized HA is biocompatible and that bone formation on the N-surface is enhanced in the early stage of bone healing.
原文英語
頁(從 - 到)1925-1929
頁數5
期刊Journal of Dental Research
80
發行號10
DOIs
出版狀態已發佈 - 2001
對外發佈

ASJC Scopus subject areas

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