A Moderate Interleukin-6 Reduction, Not a Moderate Weight Reduction, Improves the Serum Iron Status in Diet-Induced Weight Loss with Fish Oil Supplementation

研究成果: 雜誌貢獻文章

1 引文 (Scopus)

摘要

Background & Aims: Whether moderate weight loss or a reduction in IL-6 improves the serum iron status in overweight (OW) and obese adults supplemented with or without fish oil is explored. Methods and Results: In total, 93 OW/obese Taiwanese adults with ≥2 metabolic components are randomized to a 12-week calorie-restricted diet with meal replacement alone (CRMR, n = 45) or supplemented with fish oil (CRMRF, n = 48). Mean reductions in the %body weight and serum IL-6 are 7.5% versus 5.9% and 21% versus 35% for the CRMR and CRMRF groups, respectively. In the CRMRF group, a moderate loss of IL-6 (reduced ≥35%) also significantly improves the serum iron and transferrin saturation compared to those with loss of <35% in the mean serum IL-6 or those of the CRMR group who has a moderate loss of IL-6 (reduced ≥21%) (all p < 0.05). In contrast, modest weight loss does not improve the serum iron status. Conclusions: Fish oil is ineffective as an adjunct for weight or fat loss but has beneficial effects on preserving the lean body mass. A significant improvement in the iron status is only observed in those with moderate loss of serum IL-6 supplemented with fish oil.
原文英語
期刊Molecular Nutrition and Food Research
DOIs
出版狀態接受/付印 - 一月 1 2018

指紋

Reducing Diet
Fish Oils
fish oils
interleukin-6
Weight Loss
Interleukin-6
weight loss
Iron
iron
Serum
diet
low calorie diet
lean body mass
transferrin
Transferrin
Meals
Fats
Body Weight
Diet
Weights and Measures

ASJC Scopus subject areas

  • Biotechnology
  • Food Science

引用此文

@article{efee0ff1544f4fd88c022258c608d0ae,
title = "A Moderate Interleukin-6 Reduction, Not a Moderate Weight Reduction, Improves the Serum Iron Status in Diet-Induced Weight Loss with Fish Oil Supplementation",
abstract = "Background & Aims: Whether moderate weight loss or a reduction in IL-6 improves the serum iron status in overweight (OW) and obese adults supplemented with or without fish oil is explored. Methods and Results: In total, 93 OW/obese Taiwanese adults with ≥2 metabolic components are randomized to a 12-week calorie-restricted diet with meal replacement alone (CRMR, n = 45) or supplemented with fish oil (CRMRF, n = 48). Mean reductions in the {\%}body weight and serum IL-6 are 7.5{\%} versus 5.9{\%} and 21{\%} versus 35{\%} for the CRMR and CRMRF groups, respectively. In the CRMRF group, a moderate loss of IL-6 (reduced ≥35{\%}) also significantly improves the serum iron and transferrin saturation compared to those with loss of <35{\%} in the mean serum IL-6 or those of the CRMR group who has a moderate loss of IL-6 (reduced ≥21{\%}) (all p < 0.05). In contrast, modest weight loss does not improve the serum iron status. Conclusions: Fish oil is ineffective as an adjunct for weight or fat loss but has beneficial effects on preserving the lean body mass. A significant improvement in the iron status is only observed in those with moderate loss of serum IL-6 supplemented with fish oil.",
keywords = "calorie-restricted diet with meal replacement, interleukin-6, lean body mass, omega-3 fatty acids, serum iron, weight loss",
author = "Huang, {Shih Yi} and Nindy Sabrina and Chien, {Yi Wen} and Chen, {Yi Chun} and Lin, {Shyh Hsiang} and Chang, {Jung Su}",
year = "2018",
month = "1",
day = "1",
doi = "10.1002/mnfr.201800243",
language = "English",
journal = "Molecular Nutrition and Food Research",
issn = "1613-4125",
publisher = "Wiley-VCH Verlag",

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TY - JOUR

T1 - A Moderate Interleukin-6 Reduction, Not a Moderate Weight Reduction, Improves the Serum Iron Status in Diet-Induced Weight Loss with Fish Oil Supplementation

AU - Huang, Shih Yi

AU - Sabrina, Nindy

AU - Chien, Yi Wen

AU - Chen, Yi Chun

AU - Lin, Shyh Hsiang

AU - Chang, Jung Su

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background & Aims: Whether moderate weight loss or a reduction in IL-6 improves the serum iron status in overweight (OW) and obese adults supplemented with or without fish oil is explored. Methods and Results: In total, 93 OW/obese Taiwanese adults with ≥2 metabolic components are randomized to a 12-week calorie-restricted diet with meal replacement alone (CRMR, n = 45) or supplemented with fish oil (CRMRF, n = 48). Mean reductions in the %body weight and serum IL-6 are 7.5% versus 5.9% and 21% versus 35% for the CRMR and CRMRF groups, respectively. In the CRMRF group, a moderate loss of IL-6 (reduced ≥35%) also significantly improves the serum iron and transferrin saturation compared to those with loss of <35% in the mean serum IL-6 or those of the CRMR group who has a moderate loss of IL-6 (reduced ≥21%) (all p < 0.05). In contrast, modest weight loss does not improve the serum iron status. Conclusions: Fish oil is ineffective as an adjunct for weight or fat loss but has beneficial effects on preserving the lean body mass. A significant improvement in the iron status is only observed in those with moderate loss of serum IL-6 supplemented with fish oil.

AB - Background & Aims: Whether moderate weight loss or a reduction in IL-6 improves the serum iron status in overweight (OW) and obese adults supplemented with or without fish oil is explored. Methods and Results: In total, 93 OW/obese Taiwanese adults with ≥2 metabolic components are randomized to a 12-week calorie-restricted diet with meal replacement alone (CRMR, n = 45) or supplemented with fish oil (CRMRF, n = 48). Mean reductions in the %body weight and serum IL-6 are 7.5% versus 5.9% and 21% versus 35% for the CRMR and CRMRF groups, respectively. In the CRMRF group, a moderate loss of IL-6 (reduced ≥35%) also significantly improves the serum iron and transferrin saturation compared to those with loss of <35% in the mean serum IL-6 or those of the CRMR group who has a moderate loss of IL-6 (reduced ≥21%) (all p < 0.05). In contrast, modest weight loss does not improve the serum iron status. Conclusions: Fish oil is ineffective as an adjunct for weight or fat loss but has beneficial effects on preserving the lean body mass. A significant improvement in the iron status is only observed in those with moderate loss of serum IL-6 supplemented with fish oil.

KW - calorie-restricted diet with meal replacement

KW - interleukin-6

KW - lean body mass

KW - omega-3 fatty acids

KW - serum iron

KW - weight loss

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