A model for tumor cell killing by topoisomerase poisons

H. Zhang, P. D'Arpa, Leroy-Fong Liu

研究成果: 雜誌貢獻文章同行評審

173 引文 斯高帕斯(Scopus)

摘要

Our model proposes that topoisomerase-targeting antitumor drugs form reversible drug-enzyme-DNA complexes that collide with the DNA and RNA synthesis machineries. On collisions, the complexes lose their reversibility, and generate lethal double-strand DNA breaks. Further investigations of topoisomerase action will allow this model to be refined, and may ultimately lead to the development of more effective anticancer drugs.

原文英語
頁(從 - 到)23-26
頁數4
期刊Cancer Cells
2
發行號1
出版狀態已發佈 - 1990
對外發佈Yes

ASJC Scopus subject areas

  • Cancer Research

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