A model for tumor cell killing by topoisomerase poisons

H. Zhang, P. D'Arpa, Leroy-Fong Liu

研究成果: 雜誌貢獻文章

172 引文 (Scopus)

摘要

Our model proposes that topoisomerase-targeting antitumor drugs form reversible drug-enzyme-DNA complexes that collide with the DNA and RNA synthesis machineries. On collisions, the complexes lose their reversibility, and generate lethal double-strand DNA breaks. Further investigations of topoisomerase action will allow this model to be refined, and may ultimately lead to the development of more effective anticancer drugs.

原文英語
頁(從 - 到)23-26
頁數4
期刊Cancer Cells
2
發行號1
出版狀態已發佈 - 1990
對外發佈Yes

指紋

Poisons
Double-Stranded DNA Breaks
DNA
Pharmaceutical Preparations
Antineoplastic Agents
Neoplasms
RNA
Enzymes

ASJC Scopus subject areas

  • Cancer Research

引用此文

A model for tumor cell killing by topoisomerase poisons. / Zhang, H.; D'Arpa, P.; Liu, Leroy-Fong.

於: Cancer Cells, 卷 2, 編號 1, 1990, p. 23-26.

研究成果: 雜誌貢獻文章

Zhang, H, D'Arpa, P & Liu, L-F 1990, 'A model for tumor cell killing by topoisomerase poisons', Cancer Cells, 卷 2, 編號 1, 頁 23-26.
Zhang, H. ; D'Arpa, P. ; Liu, Leroy-Fong. / A model for tumor cell killing by topoisomerase poisons. 於: Cancer Cells. 1990 ; 卷 2, 編號 1. 頁 23-26.
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