A microfluidic labchip for angiogenesis inhibitor studies via multi-gradients of cancer and fibroblast stimuli

Cheng Hao Chin, Yi Liang Chiu, Kang Yun Lee, Cheng Hsien Liu

研究成果: 書貢獻/報告類型會議貢獻

摘要

Recently, the study of in vitro capillary network using microfluidic devices by generating single concentration gradient have uncovered many biological information of angiogenesis. However, the platform for angiogenesis inhibitors have not been proposed. In this study, we have developed a microfluidic device for generation of multi gradients to stimuli cancer-induced angiogenesis and fibroblast-induced angiogenesis simultaneously. The device features an interaction chamber, connected to the surrounding channels with radian shaped low-height structures used to locate clusters of cells. The formation of multiple gradients is achieved in the interaction chamber through diffusion and sustained by continuous perfusion. Microfluidic valve was developed to control the direction of flow for trapping cells of different types respectively. We show that our device could generate multiple concentration gradient and trap clusters of cells. These results demonstrated that our device is able to stimuli the angiogenesis and can be used to do the angiogenesis inhibitor study.

原文英語
主出版物標題2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
發行者Institute of Electrical and Electronics Engineers Inc.
頁面363-366
頁數4
ISBN(列印)9781479989553
DOIs
出版狀態已發佈 - 八月 5 2015
事件18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 - Anchorage, 美国
持續時間: 六月 21 2015六月 25 2015

其他

其他18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
國家美国
城市Anchorage
期間6/21/156/25/15

    指紋

ASJC Scopus subject areas

  • Instrumentation
  • Electrical and Electronic Engineering

引用此

Chin, C. H., Chiu, Y. L., Lee, K. Y., & Liu, C. H. (2015). A microfluidic labchip for angiogenesis inhibitor studies via multi-gradients of cancer and fibroblast stimuli. 於 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 (頁 363-366). [7180936] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/TRANSDUCERS.2015.7180936