摘要

Cancer is one of the leading causes of death globally. To simulate a similar environment of human tissue is the difficulty in cancer research. The development of 3D culture model is used to imitate the environment to provide a potential research strategy. Matrigel is the most commonly used material for 3D culture models. However, it is derived from murine tumors, unsuitable for clinical applications. In this study, the methacrylated gelatin (GelMA) was blended with type I collagen as a biomaterial in our microfluidic device. We further optimized the device design; it can perform entirely experimental functions without requiring complicated parts such as pumps and valves. On this microfluidic platform, the biocompatible hydrogel and cells could be patterned via liquid dielectrophoresis (LDEP) and dielectrophoretic force (DEP). The experimental results demonstrated that the human lung cancer cells were patterned via both DEP/LDEP and light-curing hydrogel with low cell mortality. The patterned cells' mortality rate is less than 5% after 24 hr of cultivation. Our results suggest the potential of this device for future clinical cancer study applications. Furthermore, we also expect to achieve bionic tumors and explore the interaction between 3D cell models and drugs.
原文英語
主出版物標題21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
發行者Institute of Electrical and Electronics Engineers Inc.
頁面479-482
頁數4
ISBN(電子)9781665412674
DOIs
出版狀態已發佈 - 六月 2021
事件21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021 - Virtual, Online, 美国
持續時間: 六月 20 2021六月 25 2021

出版系列

名字21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021

會議

會議21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
國家/地區美国
城市Virtual, Online
期間6/20/216/25/21

ASJC Scopus subject areas

  • 電氣與電子工程
  • 機械工業
  • 控制和優化
  • 儀器

指紋

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