摘要

Asthma is a disease about lower respiratory tract inflammation. A global survey shows that there are about 230 million people with asthma. Asthma is an important issue of public health in the developed and developing countries. We propose a stretchable microfluidic bronchial chip made by polydimethylsiloxane (PDMS) and glass for studying the effects of cell stretching in asthma in vitro. The bronchial smooth muscle cells (BSMC) were cultured on microfluidic chip under a continuous stretching and release mimicking human breathing. Stretching device consists of 3D printer components, a servo motor and a control panel. We have demonstrated that regular stretching of cells affect its properties. We performed stretching of cells with 13% elongation in 15 cycle per minute for 2 days. The stretching affected cell alignment of bronchial smooth muscle cells. We observed that direction of cell growth and cell stretching direction are perpendicular to each other.
原文英語
主出版物標題NEMS 2018 - 13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems
發行者Institute of Electrical and Electronics Engineers Inc.
頁面36-39
頁數4
ISBN(電子)9781538652732
DOIs
出版狀態已發佈 - 十二月 3 2018
事件13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2018 - Singapore, 新加坡
持續時間: 四月 22 2018四月 26 2018

會議

會議13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2018
國家/地區新加坡
城市Singapore
期間4/22/184/26/18

ASJC Scopus subject areas

  • 生物醫學工程
  • 電氣與電子工程
  • 儀器

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