A Microfluidic Approach for Studying Responses of Bronchial Smooth Muscle Cells Stretching

Chun Hui Sung, Yao Fei Chan, Kang Yun Lee, Sheng Ming Wu, Cheng Hsien Liu

研究成果: 書貢獻/報告類型會議貢獻

摘要

Asthma is a disease about lower respiratory tract inflammation. A global survey shows that there are about 230 million people with asthma. Asthma is an important issue of public health in the developed and developing countries. We propose a stretchable microfluidic bronchial chip made by polydimethylsiloxane (PDMS) and glass for studying the effects of cell stretching in asthma in vitro. The bronchial smooth muscle cells (BSMC) were cultured on microfluidic chip under a continuous stretching and release mimicking human breathing. Stretching device consists of 3D printer components, a servo motor and a control panel. We have demonstrated that regular stretching of cells affect its properties. We performed stretching of cells with 13% elongation in 15 cycle per minute for 2 days. The stretching affected cell alignment of bronchial smooth muscle cells. We observed that direction of cell growth and cell stretching direction are perpendicular to each other.
原文英語
主出版物標題NEMS 2018 - 13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems
發行者Institute of Electrical and Electronics Engineers Inc.
頁面36-39
頁數4
ISBN(電子)9781538652732
DOIs
出版狀態已發佈 - 十二月 3 2018
事件13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2018 - Singapore, 新加坡
持續時間: 四月 22 2018四月 26 2018

會議

會議13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2018
國家新加坡
城市Singapore
期間4/22/184/26/18

指紋

smooth muscle
muscle cells
Microfluidics
Stretching
Muscle
asthma
Cells
cells
3D printers
chips
control boards
public health
printers
Cell growth
Public health
Polydimethylsiloxane
breathing
Developing countries
elongation
Elongation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Electrical and Electronic Engineering
  • Instrumentation

引用此文

Sung, C. H., Chan, Y. F., Lee, K. Y., Wu, S. M., & Liu, C. H. (2018). A Microfluidic Approach for Studying Responses of Bronchial Smooth Muscle Cells Stretching. 於 NEMS 2018 - 13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (頁 36-39). [8556978] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NEMS.2018.8556978

A Microfluidic Approach for Studying Responses of Bronchial Smooth Muscle Cells Stretching. / Sung, Chun Hui; Chan, Yao Fei; Lee, Kang Yun; Wu, Sheng Ming; Liu, Cheng Hsien.

NEMS 2018 - 13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems. Institute of Electrical and Electronics Engineers Inc., 2018. p. 36-39 8556978.

研究成果: 書貢獻/報告類型會議貢獻

Sung, CH, Chan, YF, Lee, KY, Wu, SM & Liu, CH 2018, A Microfluidic Approach for Studying Responses of Bronchial Smooth Muscle Cells Stretching. 於 NEMS 2018 - 13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems., 8556978, Institute of Electrical and Electronics Engineers Inc., 頁 36-39, 13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2018, Singapore, 新加坡, 4/22/18. https://doi.org/10.1109/NEMS.2018.8556978
Sung CH, Chan YF, Lee KY, Wu SM, Liu CH. A Microfluidic Approach for Studying Responses of Bronchial Smooth Muscle Cells Stretching. 於 NEMS 2018 - 13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems. Institute of Electrical and Electronics Engineers Inc. 2018. p. 36-39. 8556978 https://doi.org/10.1109/NEMS.2018.8556978
Sung, Chun Hui ; Chan, Yao Fei ; Lee, Kang Yun ; Wu, Sheng Ming ; Liu, Cheng Hsien. / A Microfluidic Approach for Studying Responses of Bronchial Smooth Muscle Cells Stretching. NEMS 2018 - 13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems. Institute of Electrical and Electronics Engineers Inc., 2018. 頁 36-39
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