A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression

Pao Yen Lin, Shih Yi Huang, Kuan Pin Su

研究成果: 雜誌貢獻文章同行評審

345 引文 斯高帕斯(Scopus)

摘要

Background: On the basis of evidence from studies showing the antidepressant effects of omega-3 polyunsaturated fatty acids and the inverse relation between fish consumption and the prevalence of depression, the phospholipid hypothesis seems promising in ascertaining the etiology and treatment of depression. Although several studies have shown lower levels of omega-3 (n-3) polyunsaturated fatty acids in depressive patients, the results of individual polyunsaturated fatty acids, including docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and the omega-6 (n-6) polyunsaturated fatty acid arachidonic acid (AA), were inconsistent. Methods: Weconducted the meta-analyses of 14 studies comparing the levels of polyunsaturated fatty acids between depressive patients and control subjects. The effect size of each study was synthesized by using a random effects model. Results: Compared with control subjects, the levels of EPA, DHA, and total n-3 polyunsaturated fatty acids were significantly lower in depressive patients. There was no significant change in AA or total n-6 polyunsaturated fatty acids. Conclusions: The results showed lower levels of EPA, DHA, and total n-3 polyunsaturated fatty acids in patients with depression, thus implying that n-3 polyunsaturated fatty acids play a role in the pathogenesis of depression. Our findings provide further support to the phospholipid hypothesis of depression and a rationale for using n-3 polyunsaturated fatty acids as an alternative treatment for depression. With these results, future studies examining specific roles of DHA and EPA in different clusters of depressive symptoms are warranted.

原文英語
頁(從 - 到)140-147
頁數8
期刊Biological Psychiatry
68
發行號2
DOIs
出版狀態已發佈 - 七月 15 2010

ASJC Scopus subject areas

  • 生物精神病學

指紋

深入研究「A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression」主題。共同形成了獨特的指紋。

引用此