A lytic viral long noncoding RNA modulates the function of a latent protein

Mel Campbell, Kevin Y. Kim, Pei Ching Chang, Steve Huerta, Bogdan Shevchenko, Don Hong Wang, Chie Izumiya, Hsing Jien Kung, Yoshihiro Izumiya

研究成果: 雜誌貢獻文章同行評審

49 引文 斯高帕斯(Scopus)

摘要

Latent Kaposi's sarcoma-associated herpesvirus (KSHV) episomes are coated with viral latency-associated nuclear antigen (LANA). In contrast, LANA rapidly disassociates from episomes during reactivation. Lytic KSHV expresses polyadenylated nuclear RNA (PAN RNA), a long noncoding RNA (lncRNA). We report that PAN RNA promotes LANA-episome disassociation through an interaction with LANA which facilitates LANA sequestration away from KSHV episomes during reactivation. These findings suggest that KSHV may have evolved an RNA aptamer to regulate latent protein function.
原文英語
頁(從 - 到)1843-1848
頁數6
期刊Journal of Virology
88
發行號3
DOIs
出版狀態已發佈 - 二月 1 2014

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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