A gradient of sequence divergence in the human adult α-globin duplication units

J. F. Hess, C. W. Schmid, C. K.J. Shen

研究成果: 雜誌貢獻文章同行評審

44 引文 斯高帕斯(Scopus)

摘要

The nucleotide sequences of the two 5′-homology blocks of human α-globin gene duplication units were determined. The sequence difference between the two blocks is essentially zero in the 5′ portions, and increases gradually toward the 3′ ends until it reaches a value of 18 percent. This gradient of sequence divergence is similar to the distribution of the frequencies of gene conversion along several loci in Ascobolus and yeast. Hot spots for initiation of gene correction processes appear to exist near the 5′ ends of the human α-globin duplication units. The data provide the physical evidence for polar gene correction process in a mammalian genome.

原文英語
頁(從 - 到)67-70
頁數4
期刊Science
226
發行號4670
DOIs
出版狀態已發佈 - 1984
對外發佈Yes

ASJC Scopus subject areas

  • General

指紋 深入研究「A gradient of sequence divergence in the human adult α-globin duplication units」主題。共同形成了獨特的指紋。

引用此