A functional circuit formed by the autonomic nerves and myofibroblasts controls mammalian alveolar formation for gas exchange

Kuan Zhang, Erica Yao, Shao An Wang, Ethan Chuang, Julia Wong, Liliana Minichiello, Andrew Schroeder, Walter Eckalbar, Paul J. Wolters, Pao Tien Chuang

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

Alveolar formation increases the surface area for gas exchange. A molecular understanding of alveologenesis remains incomplete. Here, we show that the autonomic nerve and alveolar myofibroblast form a functional unit in mice. Myofibroblasts secrete neurotrophins to promote neurite extension/survival, whereas neurotransmitters released from autonomic terminals are necessary for myofibroblast proliferation and migration, a key step in alveologenesis. This establishes a functional link between autonomic innervation and alveolar formation. We also discover that planar cell polarity (PCP) signaling employs a Wnt-Fz/Ror-Vangl cascade to regulate the cytoskeleton and neurotransmitter trafficking/release from the terminals of autonomic nerves. This represents a new aspect of PCP signaling in conferring cellular properties. Together, these studies offer molecular insight into how autonomic activity controls alveolar formation. Our work also illustrates the fundamental principle of how two tissues (e.g., nerves and lungs) interact to build alveoli at the organismal level.
原文英語
頁(從 - 到)1566-1581.e7
期刊Developmental Cell
57
發行號13
DOIs
出版狀態已發佈 - 7月 11 2022

ASJC Scopus subject areas

  • 分子生物學
  • 生物化學、遺傳與分子生物學 (全部)
  • 發展生物學
  • 細胞生物學

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