A double-blind, placebo-controlled study of naltrexone in the treatment of alcohol dependence in Taiwan

Ming Chyi Huang, Chun Hsin Chen, Jeng Ming Yu, Chiao Chicy Chen

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)

摘要

The aim of this study was to investigate the effectiveness of naltrexone in Taiwanese Han males with alcohol dependence. In conjunction with limited supportive psychotherapy, 40 alcoholic patients, who met Diagnostic and Statistical Manual version III revised (DSM-III-R) criteria for alcohol dependence, were assigned to a randomized double-blind, placebo-controlled trial of naltrexone hydrochloride (50 mg/day) for 14 weeks following alcohol detoxification. Among recruited patients, 45% (n = 9/20) of the naltrexone-treated subjects and 35% (n = 7/20) of the placebo-treated subjects dropped out (p = 0.374). The relapse rates between the two groups were not significant (p = 0.671). Subjects taking naltrexone reported less alcohol craving compared with placebo-treated subjects. In support of previous reports, the present results suggest that naltrexone may be safe and effective in craving reduction in alcohol-dependent subjects.

原文英語
頁(從 - 到)289-292
頁數4
期刊Addiction Biology
10
發行號3
DOIs
出版狀態已發佈 - 九月 2005

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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