A Decrease in the Percentage of CD3+ Cells Is Correlated With Clinical Improvement During Plasmapheresis in Patients With Myasthenia Gravis

Pei Ju Chien, Jiann Horng Yeh, Chwen Ming Shih, Yu Mei Hsueh, Mei Chieh Chen, Hou Chang Chiu

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

摘要

Plasmapheresis not only removes circulating antibodies but also modulates cellular immunity, including lymphocyte subsets. To investigate the effect of double-filtration plasmapheresis (DFPP) on the ratio of lymphocyte subsets in patients with myasthenia gravis (MG), we examined the percentages of B-cells, T-cells, T helper (Th) cells, T suppressor (Ts) cells, natural killer (NK) cells, NKT cells, and Th/Ts ratio before and after a single DFPP session and after a course of DFPP. A total of 26 patients were recruited; their peripheral blood lymphocyte subsets were assayed using flow cytometry. After a single session of DFPP treatment, the percentages of T-cells (P=0.0200), Th cells (P=0.0178), and the Th/Ts ratio (P=0.0309) decreased significantly, whereas the percentage of NK cells (P=0.0007) increased significantly. More importantly, after one course of DFPP treatment, the reduced clinical quantitative MG (QMG) score was correlated with the decrease of the percentage of T-cells (r=0.5005, P=0.0092). Fourteen thymectomized MG patients had decreased percentages of T-cells (P=0.0304) and Th cells (P=0.0444), whereas they had increased NK cells (P=0.0197) after a single DFPP session. Here, transiently decreased percentages of T-cells after the full DFPP course could enhance the effectiveness of plasmapheresis for MG patients. Artificial Organs
原文英語
頁(從 - 到)211-216
頁數6
期刊Artificial Organs
37
發行號2
DOIs
出版狀態已發佈 - 二月 2013

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Bioengineering
  • Medicine (miscellaneous)

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