A correlation between polyomavirus JC virus quantification and genotypes in renal transplantation

Wen Yao Yin, Ming Chi Lu, Ming Che Lee, Su Chin Liu, Teng Yi Lin, Ning Sheng Lai

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)

摘要

Objective: To determine whether the John Cunningham virus (JCV) viral load and the multigenotypes in viruria are correlated with transplant patients. Methods: The urine of 60 renal transplant patients and 60 healthy controls were screened. We used quantitative real-time polymerase chain reaction and capillary electrophoresis to assess viral load and genotype respectively. Results: The incidence of viruria and viral load were higher in transplant patients with P = .0092 and P = .0094, respectively. The incidence of different genotype in transplant patients versus controls was 8.3% versus 13.3% for single genotype, 26.7% versus 5% for 2 genotypes, and 5% versus 0% for multigenotypes (P = .0004). The incidence of more than 2 genotypes was high in people with a high viral load and closely related with the transplant patients (P = .007). Conclusions: Not only viral load but also genotypes are important as a screening parameter to understand the immune milieu of the patients to prevent subsequent complications like polyomavirus nephropathy, infection, and malignancy.

原文英語
頁(從 - 到)53-58
頁數6
期刊American Journal of Surgery
200
發行號1
DOIs
出版狀態已發佈 - 7月 2010
對外發佈

ASJC Scopus subject areas

  • 手術

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