A Convenient Synthesis of Antihyperlipoproteinemic Agent Gemfibrozil

Hui‐Po ‐P Wang, On Lee, Chin‐Tsai ‐T Fan, Lain‐Tze ‐T Lee

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)

摘要

A new synthesis of antihyperlipoproteinemic agent 2,2‐dimethyl‐5‐(2,5‐dimethylphenoxy)pentanoic acid (gemfibrozil, 1) is developed via hydrogenolysis of a novel β‐lactone 6, prepared from [2+2] cycloaddition of 3‐(2,5‐dimethylphenoxy)propanal with dimethylketene. The mild conditions applied in this process are especially convenient for the preparation of gemfibrozil on an industrial scale of production.

原文英語
頁(從 - 到)569-572
頁數4
期刊Journal of the Chinese Chemical Society
42
發行號3
DOIs
出版狀態已發佈 - 1995
對外發佈

ASJC Scopus subject areas

  • 化學 (全部)

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