A comparison of safety, tolerability and immunogenicity of Oka/Merck varicella vaccine and VARILRIX™ in healthy children

Yu Lung Lau, S. J.Rupert Vessey, Ivan S.F. Chan, Tsz Leung Lee, Li Min Huang, Chin Yun Lee, Tzou-Yien Lin, Bee Wah Lee, Kow Kwan, Siti M. Kasim, Christina Y. Chan, Karen M. Kaplan, Daniel J. Distefano, Anna L. Harmon, Amy Golie, Jonathan Hartzel, Jin Xu, Shu Li, Holly Matthews, Jerald C. SadoffAlan Shaw

研究成果: 雜誌貢獻文章

41 引文 斯高帕斯(Scopus)

摘要

This study compared safety, tolerability, and immunogenicity of the Oka/Merck varicella vaccine and VARILRIX™ [Oka-RIT strain SmithKline Beecham Biologicals] in healthy children 12-24 months of age. Subjects were randomized in this double blind study to receive either a single dose of Oka/Merck varicella vaccine, (∼50,000 plaque forming units (PFU), Group A or ∼16,000PFU, Group B) or 1 dose of VARILRIX™, (∼40,000PFU/dose, Group C). Safety profiles in each treatment group were similar. The proportions of subjects achieving a 6-week postvaccination titer ≥5 gpELISA units in Groups A, B or C were 97.1, 95.2 and 85.6%, respectively.

原文英語
頁(從 - 到)2942-2949
頁數8
期刊Vaccine
20
發行號23-24
DOIs
出版狀態已發佈 - 七月 26 2002
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

引用此

Lau, Y. L., Vessey, S. J. R., Chan, I. S. F., Lee, T. L., Huang, L. M., Lee, C. Y., Lin, T-Y., Lee, B. W., Kwan, K., Kasim, S. M., Chan, C. Y., Kaplan, K. M., Distefano, D. J., Harmon, A. L., Golie, A., Hartzel, J., Xu, J., Li, S., Matthews, H., ... Shaw, A. (2002). A comparison of safety, tolerability and immunogenicity of Oka/Merck varicella vaccine and VARILRIX™ in healthy children. Vaccine, 20(23-24), 2942-2949. https://doi.org/10.1016/S0264-410X(02)00245-1