A comparison of non-HDL and LDL cholesterol goal attainment in a large, multinational patient population: The Lipid Treatment Assessment Project 2

Raul D. Santos, David D. Waters, Lisa Tarasenko, Michael Messig, J. Wouter Jukema, Cheng Wen Chiang, Jean Ferrieres, Jo Anne M Foody

研究成果: 雜誌貢獻文章

29 引文 (Scopus)

摘要

Objective: This study evaluated the success in attaining non-HDL-cholesterol (non-HDL-C) goals in the multinational L-TAP 2 study. Methods: 9955 patients ≥20 years of age with dyslipidemia on stable lipid-lowering therapy were enrolled from nine countries. Results: Success rates for non-HDL-C goals were 86% in low, 70% in moderate, and 52% in high-risk patients (63% overall). In patients with triglycerides of >200 mg/dL success rates for non-HDL-C goals were 35% vs. 69% in those with ≤200 mg/dL (p <0.0001). Among patients attaining their LDL-C goal, 18% did not attain their non-HDL-C goal. In those with coronary disease and at least two risk factors, only 34% and 30% attained respectively their non-HDL-C and LDL-C goals. Rates of failure in attaining both LDL-C and non-HDL-C goals were highest in Latin America. Conclusions: Non-HDL-C goal attainment lagged behind LDL-C goal attainment; this gap was greatest in higher-risk patients.
原文英語
頁(從 - 到)150-153
頁數4
期刊Atherosclerosis
224
發行號1
DOIs
出版狀態已發佈 - 九月 2012

指紋

LDL Cholesterol
Cholesterol
Lipids
Population
Therapeutics
Latin America
Dyslipidemias
Coronary Disease
Triglycerides
oxidized low density lipoprotein

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

引用此文

A comparison of non-HDL and LDL cholesterol goal attainment in a large, multinational patient population : The Lipid Treatment Assessment Project 2. / Santos, Raul D.; Waters, David D.; Tarasenko, Lisa; Messig, Michael; Jukema, J. Wouter; Chiang, Cheng Wen; Ferrieres, Jean; Foody, Jo Anne M.

於: Atherosclerosis, 卷 224, 編號 1, 09.2012, p. 150-153.

研究成果: 雜誌貢獻文章

Santos, RD, Waters, DD, Tarasenko, L, Messig, M, Jukema, JW, Chiang, CW, Ferrieres, J & Foody, JAM 2012, 'A comparison of non-HDL and LDL cholesterol goal attainment in a large, multinational patient population: The Lipid Treatment Assessment Project 2', Atherosclerosis, 卷 224, 編號 1, 頁 150-153. https://doi.org/10.1016/j.atherosclerosis.2012.06.052
Santos, Raul D. ; Waters, David D. ; Tarasenko, Lisa ; Messig, Michael ; Jukema, J. Wouter ; Chiang, Cheng Wen ; Ferrieres, Jean ; Foody, Jo Anne M. / A comparison of non-HDL and LDL cholesterol goal attainment in a large, multinational patient population : The Lipid Treatment Assessment Project 2. 於: Atherosclerosis. 2012 ; 卷 224, 編號 1. 頁 150-153.
@article{d5ffff0aca0e49b2b514d73a579f726a,
title = "A comparison of non-HDL and LDL cholesterol goal attainment in a large, multinational patient population: The Lipid Treatment Assessment Project 2",
abstract = "Objective: This study evaluated the success in attaining non-HDL-cholesterol (non-HDL-C) goals in the multinational L-TAP 2 study. Methods: 9955 patients ≥20 years of age with dyslipidemia on stable lipid-lowering therapy were enrolled from nine countries. Results: Success rates for non-HDL-C goals were 86{\%} in low, 70{\%} in moderate, and 52{\%} in high-risk patients (63{\%} overall). In patients with triglycerides of >200 mg/dL success rates for non-HDL-C goals were 35{\%} vs. 69{\%} in those with ≤200 mg/dL (p <0.0001). Among patients attaining their LDL-C goal, 18{\%} did not attain their non-HDL-C goal. In those with coronary disease and at least two risk factors, only 34{\%} and 30{\%} attained respectively their non-HDL-C and LDL-C goals. Rates of failure in attaining both LDL-C and non-HDL-C goals were highest in Latin America. Conclusions: Non-HDL-C goal attainment lagged behind LDL-C goal attainment; this gap was greatest in higher-risk patients.",
keywords = "Coronary heart disease, LDL-cholesterol, Non-HDL cholesterol, Risk factors, Triglycerides",
author = "Santos, {Raul D.} and Waters, {David D.} and Lisa Tarasenko and Michael Messig and Jukema, {J. Wouter} and Chiang, {Cheng Wen} and Jean Ferrieres and Foody, {Jo Anne M}",
year = "2012",
month = "9",
doi = "10.1016/j.atherosclerosis.2012.06.052",
language = "English",
volume = "224",
pages = "150--153",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - A comparison of non-HDL and LDL cholesterol goal attainment in a large, multinational patient population

T2 - The Lipid Treatment Assessment Project 2

AU - Santos, Raul D.

AU - Waters, David D.

AU - Tarasenko, Lisa

AU - Messig, Michael

AU - Jukema, J. Wouter

AU - Chiang, Cheng Wen

AU - Ferrieres, Jean

AU - Foody, Jo Anne M

PY - 2012/9

Y1 - 2012/9

N2 - Objective: This study evaluated the success in attaining non-HDL-cholesterol (non-HDL-C) goals in the multinational L-TAP 2 study. Methods: 9955 patients ≥20 years of age with dyslipidemia on stable lipid-lowering therapy were enrolled from nine countries. Results: Success rates for non-HDL-C goals were 86% in low, 70% in moderate, and 52% in high-risk patients (63% overall). In patients with triglycerides of >200 mg/dL success rates for non-HDL-C goals were 35% vs. 69% in those with ≤200 mg/dL (p <0.0001). Among patients attaining their LDL-C goal, 18% did not attain their non-HDL-C goal. In those with coronary disease and at least two risk factors, only 34% and 30% attained respectively their non-HDL-C and LDL-C goals. Rates of failure in attaining both LDL-C and non-HDL-C goals were highest in Latin America. Conclusions: Non-HDL-C goal attainment lagged behind LDL-C goal attainment; this gap was greatest in higher-risk patients.

AB - Objective: This study evaluated the success in attaining non-HDL-cholesterol (non-HDL-C) goals in the multinational L-TAP 2 study. Methods: 9955 patients ≥20 years of age with dyslipidemia on stable lipid-lowering therapy were enrolled from nine countries. Results: Success rates for non-HDL-C goals were 86% in low, 70% in moderate, and 52% in high-risk patients (63% overall). In patients with triglycerides of >200 mg/dL success rates for non-HDL-C goals were 35% vs. 69% in those with ≤200 mg/dL (p <0.0001). Among patients attaining their LDL-C goal, 18% did not attain their non-HDL-C goal. In those with coronary disease and at least two risk factors, only 34% and 30% attained respectively their non-HDL-C and LDL-C goals. Rates of failure in attaining both LDL-C and non-HDL-C goals were highest in Latin America. Conclusions: Non-HDL-C goal attainment lagged behind LDL-C goal attainment; this gap was greatest in higher-risk patients.

KW - Coronary heart disease

KW - LDL-cholesterol

KW - Non-HDL cholesterol

KW - Risk factors

KW - Triglycerides

UR - http://www.scopus.com/inward/record.url?scp=84865388510&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865388510&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2012.06.052

DO - 10.1016/j.atherosclerosis.2012.06.052

M3 - Article

C2 - 22818564

AN - SCOPUS:84865388510

VL - 224

SP - 150

EP - 153

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 1

ER -