A community-based RCT for oral cancer screening with toluidine blue

W. W Y Su, A. M F Yen, S. Y H Chiu, T. H H Chen

研究成果: 雜誌貢獻文章

21 引文 斯高帕斯(Scopus)

摘要

Early detection of oral premalignant lesions (OPMLs) by visual inspection with toluidine blue has not been addressed. We conducted a community-based randomized controlled trial to assess whether using toluidine blue as an adjunctive tool for visual screening had a higher detection rate of OPMLs and could further reduce the incidence of oral cancer. In 2000, in Keelung, we randomly assigned a total of 7975 individuals, aged 15 years or older and with high-risk oral habits, to either the toluidine-blue-screened (TBS) group or the visual screening group. Results showed 5% more oral premalignant lesions and 79% more oral submucous fibrosis detected in the TBS group than in the control group. After a five-year follow-up ascertaining oral cancer development through linkage to the National Cancer Registry, the incidence rate in the TBS group (28.0 x 10-5) was non-significantly 21% lower than that in the control group (35.4 × 10-5).
原文英語
頁(從 - 到)933-937
頁數5
期刊Journal of Dental Research
89
發行號9
DOIs
出版狀態已發佈 - 九月 2010
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)

引用此