A case of simultaneous multiple gastric cancers with p53 gene mutation.

S. Y. Lin, M. D. Lee, C. K. Wang, Y. J. Chen, J. G. Chang

研究成果: 雜誌貢獻文章

摘要

Simultaneous multiple gastric cancers are rarely observed in clinical practice, and its association with p53 gene mutation has not been mentioned in any previous reports. We report a case of advanced gastric cancer with two primary lesions in the stomach who received total gastrectomy. Tumor and surrounding normal tissues from the surgical specimen were studied by using polymerase chain reaction-single strand conformation polymorphism analysis, restriction enzyme digestion method and direct sequencing. Point mutations of p53 gene at codon 248 (CGG-->TGG) were found in both primary tumor foci. The patient developed cancerous peritonitis eight months after the operation and expired six months later. This report suggests that p53 gene mutation can occur at an earlier stage in the tumorigenesis of gastric cancer than previously reported and it might be associated with an unusual clinical and pathological presentation.

原文英語
頁(從 - 到)35-39
頁數5
期刊Kaohsiung Journal of Medical Sciences
10
發行號1
出版狀態已發佈 - 一月 1994
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Medicine(all)

引用此

Lin, S. Y., Lee, M. D., Wang, C. K., Chen, Y. J., & Chang, J. G. (1994). A case of simultaneous multiple gastric cancers with p53 gene mutation. Kaohsiung Journal of Medical Sciences, 10(1), 35-39.