A bayesian network meta-analysis on comparisons of enamel matrix derivatives, guided tissue regeneration and their combination therapies

Yu Kang Tu, Ian Needleman, Leandro Chambrone, Hsein Kun Lu, Clovis Mariano Faggion

研究成果: 雜誌貢獻文章

77 引文 (Scopus)

摘要

Aims Guided tissue regeneration (GTR) and enamel matrix derivatives (EMD) are two popular regenerative treatments for periodontal infrabony lesions. Both have been used in conjunction with other regenerative materials. We conducted a Bayesian network meta-analysis of randomized controlled trials on treatment effects of GTR, EMD and their combination therapies. Material and Methods A systematic literature search was conducted using the Medline, EMBASE, LILACS and CENTRAL databases up to and including June 2011. Treatment outcomes were changes in probing pocket depth (PPD), clinical attachment level (CAL) and infrabony defect depth. Different types of bone grafts were treated as one group and so were barrier membranes. Results A total of 53 studies were included in this review, and we found small differences between regenerative therapies which were non-significant statistically and clinically. GTR and GTR-related combination therapies achieved greater PPD reduction than EMD and EMD-related combination therapies. Combination therapies achieved slightly greater CAL gain than the use of EMD or GTR alone. GTR with BG achieved greatest defect fill. Conclusion Combination therapies performed better than single therapies, but the additional benefits were small. Bayesian network meta-analysis is a promising technique to compare multiple treatments. Further analysis of methodological characteristics will be required prior to clinical recommendations.
原文英語
頁(從 - 到)303-314
頁數12
期刊Journal of Clinical Periodontology
39
發行號3
DOIs
出版狀態已發佈 - 三月 2012

指紋

Guided Tissue Regeneration
Dental Enamel
Therapeutics
Network Meta-Analysis
Randomized Controlled Trials
Databases
Transplants
Bone and Bones
Membranes

ASJC Scopus subject areas

  • Periodontics

引用此文

A bayesian network meta-analysis on comparisons of enamel matrix derivatives, guided tissue regeneration and their combination therapies. / Tu, Yu Kang; Needleman, Ian; Chambrone, Leandro; Lu, Hsein Kun; Faggion, Clovis Mariano.

於: Journal of Clinical Periodontology, 卷 39, 編號 3, 03.2012, p. 303-314.

研究成果: 雜誌貢獻文章

Tu, Yu Kang ; Needleman, Ian ; Chambrone, Leandro ; Lu, Hsein Kun ; Faggion, Clovis Mariano. / A bayesian network meta-analysis on comparisons of enamel matrix derivatives, guided tissue regeneration and their combination therapies. 於: Journal of Clinical Periodontology. 2012 ; 卷 39, 編號 3. 頁 303-314.
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