Aβ Aggregation inhibitors. Part 1: Synthesis and biological activity of phenylazo benzenesulfonamides

Shwu Jiuan Lin, Young Ji Shiao, Chih Wen Chi, Li Ming Yang

研究成果: 雜誌貢獻文章

22 引文 斯高帕斯(Scopus)

摘要

Phenylazo benzenesulfonamides were designed and synthesized as β-amyloid (Aβ40) fibril assembly inhibitors, and evaluated for inhibition of Aβ40 aggregation and neurotoxicity using rat cortical neurons. Compound 2 (LB-152) was the most potent compound in this study, and the para-NMe2 group on the end of the phenylazo moiety may play an important role in preventing Aβ40 fibril formation. LB-152 provides a new lead for further development of potential β-amyloid aggregation inhibitors to treat AD.
原文英語
頁(從 - 到)1173-1176
頁數4
期刊Bioorganic and Medicinal Chemistry Letters
14
發行號5
DOIs
出版狀態已發佈 - 三月 8 2004

    指紋

Keywords

  • Alzheimer's disease
  • Benzenesulfonamide
  • beta-Amyloid
  • Phenylazo

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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