尋找研究成果

搜尋概念
已選取的篩選器
2019

A critical period for the development of schizophrenia-like pathology by aberrant postnatal neurogenesis

Sheu, J. R., Hsieh, C. Y., Jayakumar, T., Tseng, M. F., Lee, H. N., Huang, S. W., Manubolu, M. & Yang, C. H., 一月 1 2019, 於 : Frontiers in Neuroscience. 13, JUN, 635.

研究成果: 雜誌貢獻文章

開啟存取
Neurogenesis
Schizophrenia
Pathology
Critical Period (Psychology)
Hallucinations
2 引文 (Scopus)
Neurogenesis
Neurons
Stroke
Recovery
Patient rehabilitation

New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury

Lu, W-J., Lin, K-H., Tseng, M-F., Yuan, K-C., Huang, H-C., Sheu, J-R. & Chen, R-J., 三月 1 2019, 於 : Journal of Cellular and Molecular Medicine. 23, 3, p. 1723-1734 12 p.

研究成果: 雜誌貢獻文章

Hemorrhagic Shock
Liver
Wounds and Injuries
Resuscitation
Therapeutics
2018

Analysis of Titin in Red and White Muscles: Crucial Role on Muscle Contractions Using a Fish Model

Wu, M. P., Chang, N. C., Chung, C. L., Chiu, W. C., Hsu, C. C., Chen, H. M., Sheu, J. R., Jayakumar, T., Chou, D. S. & Fong, T. H., 十一月 18 2018, 於 : BioMed Research International. 2018, p. 5816875 11 p., 5816875.

研究成果: 雜誌貢獻文章

Connectin
Muscle Contraction
Fish
Muscle
Muscles

An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets

Lu, W. J., Chung, C. L., Chen, R. J., Huang, L. T., Lien, L. M., Chang, C. C., Lin, K. H. & Sheu, J. R., 十一月 14 2018, 於 : Journal of Clinical Medicine. 7, 11

研究成果: 雜誌貢獻文章

Phospholipase D
Blood Platelets
Platelet Activation
Platelet Aggregation
Thrombosis

Biofuel and biochemical analysis of amphora coffeaeformis RR03, a novel marine diatom, cultivated in an open raceway pond

Rajaram, M. G., Nagaraj, S., Manjunath, M., Boopathy, A. B., Kurinjimalar, C., Rengasamy, R., Jayakumar, T., Sheu, J. R. & Li, J. Y., 六月 1 2018, 於 : Energies. 11, 6, en11061341.

研究成果: 雜誌貢獻文章

Diatoms
Ponds
Biofuels
Biomass
Fatty Acids
8 引文 (Scopus)

CME-1, a novel polysaccharide, suppresses iNOS expression in lipopolysaccharide-stimulated macrophages through ceramide-initiated protein phosphatase 2A activation

Sheu, J. R., Chen, Z. C., Hsu, M. J., Wang, S. H., Jung, K. W., Wu, W. F., Pan, S. H., Teng, R. D., Yang, C. H. & Hsieh, C. Y., 二月 1 2018, 於 : Journal of Cellular and Molecular Medicine. 22, 2, p. 999-1013 15 p.

研究成果: 雜誌貢獻文章

Protein Phosphatase 2
Ceramides
Nitric Oxide Synthase Type II
Polysaccharides
Lipopolysaccharides
開啟存取
Organometallic Compounds
Molecular Medicine
Iridium
Platelet Activation
Medicine
6 引文 (Scopus)

Hinokitiol inhibits migration of A549 lung cancer cells via suppression of MMPs and induction of antioxidant enzymes and apoptosis

Jayakumar, T., Liu, C. H., Wu, G. Y., Lee, T. Y., Manubolu, M., Hsieh, C. Y., Yang, C. H. & Sheu, J. R., 三月 22 2018, 於 : International Journal of Molecular Sciences. 19, 4, 939.

研究成果: 雜誌貢獻文章

Enzyme Induction
antioxidants
apoptosis
Cell death
Antioxidants
2 引文 (Scopus)

Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation

Shyu, R. S., Khamrang, T., Sheu, J. R., Hsia, C. W., Velusamy, M., Hsia, C. H., Chou, D. S. & Chang, C. C., 一月 1 2018, 於 : Bioinorganic Chemistry and Applications. 2018, p. 8291393 8291393.

研究成果: 雜誌貢獻文章

Iridium
Platelet Activation
Organometallics
Platelets
Collagen
1 引文 (Scopus)

Mechanism of free radical generation in platelets and primary hepatocytes: A novel electron spin resonance study

Wang, C. L., Yang, P. S., Tsao, J. T., Jayakumar, T., Wang, M. J., Sheu, J. R. & Chou, D. S., 一月 1 2018, 於 : Molecular Medicine Reports. 17, 1, p. 2061-2069 9 p.

研究成果: 雜誌貢獻文章

Electron Spin Resonance Spectroscopy
Platelets
Free Radicals
Paramagnetic resonance
Hepatocytes

Mechanisms of TQ-6, a Novel Ruthenium-Derivative Compound, against Lipopolysaccharide-Induced In Vitro Macrophage Activation and Liver Injury in Experimental Mice: The Crucial Role of p38 MAPK and NF-κB Signaling

Hsia, C-H., Velusamy, M., Jayakumar, T., Chen, Y-J., Hsia, C-W., Tsai, J-H., Teng, R-D. & Sheu, J-R., 十一月 19 2018, 於 : Cells. 7, 11

研究成果: 雜誌貢獻文章

Ruthenium Compounds
Ruthenium
Macrophage Activation
Macrophages
p38 Mitogen-Activated Protein Kinases

Molecular pharmacology and pathology of strokes

Sheu, J. R., 一月 1 2018, 於 : International Journal of Molecular Sciences. 19, 12, 4103.

研究成果: 雜誌貢獻社論

pharmacology
Molecular Pathology
pathology
Pathology
strokes
2 引文 (Scopus)
norcantharidin
Integrins
Fibrinogen
Blood Platelets
Clot Retraction
5 引文 (Scopus)

Novel iridium (III)-derived organometallic compound for the inhibition of human platelet activation

Shyu, K. G., Velusamy, M., Hsia, C. W., Yang, C. H., Hsia, C. H., Chou, D. S., Jayakumar, T., Sheu, J. R. & Li, J. Y., 五月 1 2018, 於 : International Journal of Molecular Medicine. 41, 5, p. 2589-2600 12 p.

研究成果: 雜誌貢獻文章

Organometallic Compounds
Iridium
Platelet Activation
Platelet Aggregation
Collagen
2 引文 (Scopus)

Novel therapeutic agent against platelet activation in vitro and arterial thrombosis in vivo by morin hydrate

Hsia, C. W., Wu, M. P., Velusamy, M., Hsia, C. H., Chou, D. S., Tsai, C. L., Hsu, C. Y., Jayakumar, T., Chung, C. L. & Sheu, J. R., 八月 13 2018, 於 : International Journal of Molecular Sciences. 19, 8, 2386.

研究成果: 雜誌貢獻文章

thrombosis
Platelet Activation
Platelets
platelets
Hydrates
5 引文 (Scopus)

Possible molecular targets of novel ruthenium complexes in antiplatelet therapy

Jayakumar, T., Hsu, C. Y., Khamrang, T., Hsia, C. H., Hsia, C. W., Manubolu, M. & Sheu, J. R., 六月 20 2018, 於 : International Journal of Molecular Sciences. 19, 6, 1818.

研究成果: 雜誌貢獻回顧型文獻

Ruthenium Compounds
Ruthenium
Platelets
platelets
ruthenium
3 引文 (Scopus)

Structure-antiplatelet activity relationships of novel ruthenium (ii) complexes: Investigation of its molecular targets

Hsia, C. H., Jayakumar, T., Sheu, J. R., Tsao, S. Y., Velusamy, M., Hsia, C. W., Chou, D. S., Chang, C. C., Chung, C. L., Khamrang, T. & Lin, K. C., 二月 22 2018, 於 : Molecules. 23, 2, 477.

研究成果: 雜誌貢獻文章

Ruthenium
Structure-Activity Relationship
Platelets
platelets
ruthenium
1 引文 (Scopus)

Structure⁻Activity Relationship Study of Newly Synthesized Iridium-III Complexes as Potential Series for Treating Thrombotic Diseases

Yang, C. H., Hsia, C. W., Jayakumar, T., Sheu, J. R., Hsia, C. H., Khamrang, T., Chen, Y. J., Manubolu, M. & Chang, Y., 十一月 19 2018, 於 : International Journal of Molecular Sciences. 19, 11

研究成果: 雜誌貢獻文章

Iridium
iridium
collagens
Collagen
Iridium compounds
2017
6 引文 (Scopus)

A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice

Sheu, J. R., Chen, Z. C., Jayakumar, T., Chou, D. S., Yen, T. L., Lee, H. N., Pan, S. H., Hsia, C. H., Yang, C. H. & Hsieh, C. Y., 二月 6 2017, 於 : Scientific Reports. 7, 42277.

研究成果: 雜誌貢獻文章

Stroke
Medicine
Middle Cerebral Artery Infarction
Therapeutics
JNK Mitogen-Activated Protein Kinases
3 引文 (Scopus)

A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies

Hsia, C. H., Velusamy, M., Sheu, J. R., Khamrang, T., Jayakumar, T., Lu, W. J., Lin, K. H. & Chang, C. C., 十二月 1 2017, 於 : Scientific Reports. 7, 1, 9556.

研究成果: 雜誌貢獻文章

Organometallic Compounds
Ruthenium
Fluorescein-5-isothiocyanate
Platelet Aggregation
Blood Platelets
3 引文 (Scopus)

Antiplatelet activity of a newly synthesized novel ruthenium (II): A potential role for Akt/JNK signaling

Khamrang, T., Hung, K. C., Hsia, C. H., Hsieh, C. Y., Velusamy, M., Jayakumar, T. & Sheu, J. R., 五月 1 2017, 於 : International Journal of Molecular Sciences. 18, 5, 916.

研究成果: 雜誌貢獻文章

Ruthenium
Platelets
platelets
Platelet Aggregation
ruthenium
1 引文 (Scopus)

Development of benzimidazole derivatives as novel anti-platelet drugs

Yao, W. C., Yuan, L. T., Yang, W. B., Hsia, C. H., Huang, L. T., Lee, T. Y., Sheu, J. R., Lu, W-J., Jayakumar, T. & Chen, R. J., 一月 1 2017, 於 : Current Pharmaceutical Biotechnology. 18, 7, p. 594-605 12 p.

研究成果: 雜誌貢獻文章

Thrombin
Blood Platelets
Platelet Aggregation
Pharmaceutical Preparations
Epinephrine
7 引文 (Scopus)

Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies

Lee, T. Y., Chang, C. C., Lu, W-J., Yen, T. L., Lin, K. H., Geraldine, P., Li, J. Y. & Sheu, J-R., 一月 5 2017, 於 : Scientific Reports. 7, 40002.

研究成果: 雜誌貢獻文章

Collagen Receptors
Glycoproteins
Blood Platelets
Collagen
Platelet Activation
8 引文 (Scopus)
Tabernaemontana
Silver
Nanoparticles
Lenses
Antioxidants
5 引文 (Scopus)

Ketamine, a clinically used anesthetic, inhibits vascular smooth muscle cell proliferation via PP2A-activated PI3K/Akt/ERK inhibition

Chang, Y., Li, J. Y., Jayakumar, T., Hung, S. H., Lee, W. C., Manubolu, M., Sheu, J. R. & Hsu, M. J., 十二月 1 2017, 於 : International Journal of Molecular Sciences. 18, 12, 2545.

研究成果: 雜誌貢獻文章

Phosphatidylinositol 3-Kinase
anesthetics
Enzyme inhibition
smooth muscle
Protein Phosphatase 2
33 引文 (Scopus)

Multi-targeting andrographolide, a novel NF-κB inhibitor, as a potential therapeutic agent for stroke

Yang, C. H., Yen, T. L., Hsu, C. Y., Thomas, P. A., Sheu, J. R. & Jayakumar, T., 八月 1 2017, 於 : International Journal of Molecular Sciences. 18, 8, 1638.

研究成果: 雜誌貢獻回顧型文獻

Neuroprotective Agents
Cell death
strokes
inhibitors
Stroke
4 引文 (Scopus)

New therapeutic agent against arterial thrombosis: An iridium(III)-derived organometallic compound

Hsia, C. W., Velusamy, M., Tsao, J. T., Hsia, C. H., Chou, D. S., Jayakumar, T., Lee, L. W., Li, J. Y. & Sheu, J. R., 十二月 5 2017, 於 : International Journal of Molecular Sciences. 18, 12, 2616.

研究成果: 雜誌貢獻文章

Organometallic Compounds
thrombosis
Iridium
organometallic compounds
Organometallics
5 引文 (Scopus)

Nobiletin, a citrus flavonoid, activates Vasodilator-stimulated phosphoprotein in human platelets through non-cyclic nucleotide-related mechanisms

Jayakumar, T., Lin, K. C., Lu, W-J., Lin, C. Y., Pitchairaj, G., Li, J. Y. & Sheu, J-R., 一月 1 2017, 於 : International Journal of Molecular Medicine. 39, 1, p. 174-182 9 p.

研究成果: 雜誌貢獻文章

Citrus
Flavonoids
Blood Platelets
Nucleotides
Phosphorylation

Structure-activity relationship of three synthesized benzimidazole-based oligosaccharides in human platelet activation

Chang, Y., Hsu, W. H., Yang, W. B., Jayakumar, T., Lee, T. Y., Sheu, J. R., Lu, W. J. & Li, J. Y., 十一月 1 2017, 於 : International Journal of Molecular Medicine. 40, 5, p. 1520-1528 9 p.

研究成果: 雜誌貢獻文章

Platelet Activation
Structure-Activity Relationship
Oligosaccharides
Collagen
p38 Mitogen-Activated Protein Kinases
1 引文 (Scopus)

The neuroprotective effects of Tao-Ren-Cheng-Qi Tang against embolic stroke in rats

Hsu, L. W., Shiao, W. C., Chang, N. C., Yu, M. C., Yen, T. L., Thomas, P. A., Jayakumar, T. & Sheu, J. R., 一月 31 2017, 於 : Chinese Medicine (United Kingdom). 12, 1, 7.

研究成果: 雜誌貢獻文章

Qi
Neuroprotective Agents
Stroke
Aspirin
Middle Cerebral Artery Infarction
2016
29 引文 (Scopus)
Heme Oxygenase-1
Cytoprotection
Endothelial cells
p38 Mitogen-Activated Protein Kinases
Rats
25 引文 (Scopus)

Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways

Lien, L. M., Wang, M. J., Chen, R. J., Chiu, H. C., Wu, J. L., Shen, M. Y., Chou, D. S., Sheu, J. R., Lin, K. H. & Lu, W-J., 二月 1 2016, 於 : Phytotherapy Research. 30, 2, p. 214-221 8 p.

研究成果: 雜誌貢獻文章

flavone
Glioma
Cell Movement
Cell Cycle
Growth
3 引文 (Scopus)

Novel synthetic benzimidazole-derived oligosaccharide, M3BIM, prevents ex vivo platelet aggregation and in vivo thromboembolism

Yen, T. L., Wu, M. P., Chung, C. L., Yang, W. B., Jayakumar, T., Geraldine, P., Chou, C. M., Chang, C. Y., Lu, W-J. & Sheu, J. R., 二月 17 2016, 於 : Journal of Biomedical Science. 23, 1, 26.

研究成果: 雜誌貢獻文章

Thromboembolism
Platelets
Oligosaccharides
Platelet Aggregation
Collagen
24 引文 (Scopus)

Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation

Shen, M. Y., Chen, F. Y., Hsu, J. F., Fu, R. H., Chang, C. M., Chang, C. T., Liu, C. H., Wu, J. R., Lee, A. S., Chan, H. C., Sheu, J. R., Lin, S. Z., Shyu, W. C., Sawamura, T., Chang, K. C., Hsu, C. Y. & Chen, C. H., 三月 10 2016, 於 : Blood. 127, 10, p. 1336-1345 10 p.

研究成果: 雜誌貢獻文章

Platelets
Platelet Aggregation
Oxidized LDL Receptors
LDL Lipoproteins
Agglomeration
17 引文 (Scopus)

Prevention of arterial thrombosis by nobiletin: In vitro and in vivo studies

Lu, W-J., Lin, K. C., Liu, C. P., Lin, C. Y., Wu, H. C., Chou, D. S., Geraldine, P., Huang, S. Y., Hsieh, C. Y. & Sheu, J. R., 二月 1 2016, 於 : Journal of Nutritional Biochemistry. 28, p. 1-8 8 p.

研究成果: 雜誌貢獻文章

Platelets
Thrombosis
Platelet Aggregation
Platelet Activation
Blood Platelets
10 引文 (Scopus)

The pharmacodynamics of antiplatelet compounds in thrombosis treatment

Jayakumar, T., Yang, C. H., Geraldine, P., Yen, T. L. & Sheu, J. R., 六月 2 2016, 於 : Expert Opinion on Drug Metabolism and Toxicology. 12, 6, p. 615-632 18 p.

研究成果: 雜誌貢獻回顧型文獻

Pharmacodynamics
Platelet Aggregation Inhibitors
Platelets
Thrombosis
clopidogrel