- 34,923個結果中的600 - 650
- 出版年份，標題 （降序）
2019
Induction of Fibrosis and Autophagy in Kidney Cells by Vinyl Chloride
Hsu, Y-H., Chuang, H-C., Lee, Y-H., Lin, Y-F., Chiu, Y-J., Wang, Y-L., Wu, M-S. & Chiu, H-W., 六月 17 2019, 於 : Cells. 8, 6研究成果: 雜誌貢獻 › 文章
Vinyl Chloride
Autophagy
Fibrosis
Kidney
Tissue
1
引文
(Scopus)
Induction of GNMT by 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside through proteasome-independent MYC downregulation in hepatocellular carcinoma
Kant, R., Yen, C. H., Hung, J. H., Lu, C. K., Tung, C. Y., Chang, P. C., Chen, Y. H., Tyan, Y. C. & Chen, Y. M. A., 十二月 1 2019, 於 : Scientific Reports. 9, 1, 1968.研究成果: 雜誌貢獻 › 文章
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Sarcosine
Rubiaceae
Proteasome Endopeptidase Complex
Transferases
Hepatocellular Carcinoma
1
引文
(Scopus)
Induction of nuclear protein-1 by thyroid hormone enhances platelet-derived growth factor a mediated angiogenesis in liver cancer
Chen, C. Y., Wu, S. M., Lin, Y. H., Chi, H. C., Lin, S. L., Yeh, C. T., Chuang, W. Y. & Lin, K. H., 一月 1 2019, 於 : Theranostics. 9, 8, p. 2361-2379 19 p.研究成果: 雜誌貢獻 › 文章
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Platelet-Derived Growth Factor
Liver Neoplasms
Nuclear Proteins
Thyroid Hormones
Hepatocellular Carcinoma
Inflammation associated with volume reduction in the gray matter and hippocampus of older patients with bipolar disorder
Tsai, S. Y., Gildengers, A. G., Hsu, J. L., Chung, K. H., Chen, P. H. & Huang, Y. J., 二月 1 2019, 於 : Journal of Affective Disorders. 244, p. 60-66 7 p.研究成果: 雜誌貢獻 › 文章
Interleukin-2 Receptors
Bipolar Disorder
Hippocampus
Inflammation
Tumor Necrosis Factor Receptors
Inflammatory bowel disease and bipolar disorder: A population-based cross-sectional study
Kao, L. T., Lin, H. C. & Lee, H. C., 三月 15 2019, 於 : Journal of Affective Disorders. 247, p. 120-124 5 p.研究成果: 雜誌貢獻 › 文章
Bipolar Disorder
Inflammatory Bowel Diseases
Cross-Sectional Studies
Population
Odds Ratio
Inflammatory Dietary Pattern Predicts Dyslipidemia and Anemia in Middle-Aged and Older Taiwanese Adults with Declined Kidney Function: A Cross-Sectional Population Study from 2008 to 2010
Kurniawan, A. L., Hsu, C. Y., Rau, H. H., Lin, L. Y. & Chao, J. C. J., 九月 2 2019, 於 : Nutrients. 11, 9研究成果: 雜誌貢獻 › 文章
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middle-aged adults
hyperlipidemia
renal function
Dyslipidemias
eating habits
2
引文
(Scopus)
Influence of aging and visual feedback on the stability of hand grip control in elderly adults
Lin, C. H., Sung, W. H., Chiang, S. L., Lee, S-C., Lu, L. H., Wang, P. C. & Wang, X. M., 五月 1 2019, 於 : Experimental Gerontology. 119, p. 74-81 8 p.研究成果: 雜誌貢獻 › 文章
Sensory Feedback
Hand Strength
Hand
Aging of materials
Feedback
Influence of sleep-wake cycle on body mass index in female shift-working nurses with sleep quality as mediating variable
Chang, W-P. & Yang, C-M., 十月 1 2019, 於 : Industrial Health.研究成果: 雜誌貢獻 › 文章
Sleep
Body Mass Index
Nurses
Taiwan
Teaching Hospitals
Infraclavicular brachial plexus block in adults: a comprehensive review based on a unified nomenclature system
Hsu, A-C., Tai, Y-T., Lin, K-H., Yao, H-Y., Chiang, H-L., Ho, B-Y., Yang, S-F., Lin, J-A. & Ko, C-L., 五月 10 2019, 於 : Journal of Anesthesia.研究成果: 雜誌貢獻 › 回顧型文獻
Terminology
Human Engineering
Local Anesthetics
Safety
Brachial Plexus Block
Inhibitory Effects of Scutellaria baicalensis Root Extract on Linoleic Acid Hydroperoxide-induced Lung Mitochondrial Lipid Peroxidation and Antioxidant Activities
Liau, P. R., Wu, M. S. & Lee, C. K., 六月 6 2019, 於 : Molecules. 24, 11, 2143.研究成果: 雜誌貢獻 › 文章
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antioxidants
lungs
Lipid Peroxidation
Mitochondria
mitochondria
Insights Figure for Anti-thymic stromal lymphopoietin antibody suppresses airway remodeling in asthma through reduction of MMP and CTGF
Lin, S. C., Chou, H. C., Chen, C. M. & Chiang, B. L., 八月 1 2019, 於 : Pediatric Research. 86, 2, 1 p.研究成果: 雜誌貢獻 › 文章
Airway Remodeling
Matrix Metalloproteinases
Asthma
Antibodies
thymic stromal lymphopoietin
In silico identification of thiostrepton as an inhibitor of cancer stem cell growth and an enhancer for chemotherapy in non-small-cell lung cancer
Huang, T-H., Wu, A. T. H., Cheng, T-S., Lin, K-T., Lai, C-J., Hsieh, H-W., Chang, P. M-H., Wu, C-W., Huang, C-Y. F. & Chen, K-Y., 十月 22 2019, 於 : Journal of Cellular and Molecular Medicine.研究成果: 雜誌貢獻 › 文章
Thiostrepton
Neoplastic Stem Cells
Non-Small Cell Lung Carcinoma
Computer Simulation
Drug Therapy
In silico repurposing the Rac1 inhibitor NSC23766 for treating PTTG1-high expressing clear cell renal carcinoma
Hsieh, Y. Y., Liu, T. P. & Yang, P. M., 一月 1 2019, 於 : Pathology Research and Practice.研究成果: 雜誌貢獻 › 文章
Pituitary Neoplasms
Oncogenes
Renal Cell Carcinoma
Computer Simulation
Neoplasms
In silico screening of sugar alcohol compounds to inhibit viral matrix protein VP40 of Ebola virus
Nagarajan, N., Yapp, E. K. Y., Le, N. Q. K. & Yeh, H. Y., 六月 1 2019, 於 : Molecular Biology Reports. 46, 3, p. 3315-3324 10 p.研究成果: 雜誌貢獻 › 文章
Viral Matrix Proteins
Sugar Alcohols
Ebolavirus
Computer Simulation
Sorbitol
1
引文
(Scopus)
In situ chemically crosslinked injectable hydrogels for the subcutaneous delivery of trastuzumab to treat breast cancer
Lo, Y. W., Sheu, M. T., Chiang, W. H., Chiu, Y. L., Tu, C. M., Wang, W. Y., Wu, M. H., Wang, Y. C., Lu, M. & Ho, H. O., 三月 1 2019, 於 : Acta Biomaterialia. 86, p. 280-290 11 p.研究成果: 雜誌貢獻 › 文章
Hydrogels
Hydrogel
Breast Neoplasms
Injections
Antibodies
Insomnia Increases Symptom Severity and Health Care Utilization in Patients with Fibromyalgia: A Population-based Study
Huang, C. J., Huang, C. L., Fan, Y. C., Chen, T. Y. & Tsai, P. S., 九月 1 2019, 於 : Clinical Journal of Pain. 35, 9, p. 780-785 6 p.研究成果: 雜誌貢獻 › 文章
Patient Acceptance of Health Care
Fibromyalgia
Sleep Initiation and Maintenance Disorders
Population
Odds Ratio
2
引文
(Scopus)
Instability of brain connectivity during nonrapid eye movement sleep reflects altered properties of information integration
Kung, Y. C., Li, C. W., Chen, S., Chen, S. C. J., Lo, C. Y. Z., Lane, T. J., Biswal, B., Wu, C. W. & Lin, C. P., 八月 1 2019, 於 : Human Brain Mapping. 40, 11, p. 3192-3202 11 p.研究成果: 雜誌貢獻 › 文章
Eye Movements
Sleep
Brain
Sleep Stages
Consciousness
Insulin Resistance and Cardiovascular Risks in Different Groups of Hemodialysis Patients: A Multicenter Study
Duong, T. V., Shih, C. K., Wong, T. C., Chen, H. H., Chen, T. H., Hsu, Y. H., Peng, S. J., Kuo, K. L., Liu, H. C., Lin, E. T., Su, C. T. & Yang, S. H., 一月 1 2019, 於 : BioMed Research International. 2019, p. 1541593 1541593.研究成果: 雜誌貢獻 › 文章
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Multicenter Studies
Renal Dialysis
Insulin Resistance
Insulin
Cardiovascular Diseases
Integration of Bioinformatics Resources Reveals the Therapeutic Benefits of Gemcitabine and Cell Cycle Intervention in SMAD4-Deleted Pancreatic Ductal Adenocarcinoma
Hsieh, Y. Y., Liu, T. P., Chou, C. J., Chen, H. Y., Lee, K. H. & Yang, P. M., 九月 28 2019, 於 : Genes. 10, 10研究成果: 雜誌貢獻 › 文章
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gemcitabine
Computational Biology
Cell Cycle
Adenocarcinoma
Therapeutics
Integrative settings approach to workplace health promotion to address contemporary challenges for worker health in the Asia-Pacific
Pham, C. T., Lee, C. B., Nguyen, T. L. H., Lin, J. D., Ali, S. & Chu, C., 一月 1 2019, 於 : Global Health Promotion.研究成果: 雜誌貢獻 › 文章
Health Promotion
Workplace
Health
Singapore
Taiwan
2
引文
(Scopus)
Interindividual neural differences in moral decision-making are mediated by alpha power and delta/theta phase coherence
Wolff, A., Gomez-Pilar, J., Nakao, T. & Northoff, G., 三月 14 2019, 於 : Scientific Reports. 9, 1, 4432.研究成果: 雜誌貢獻 › 文章
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Decision Making
Artificial Intelligence
Electroencephalography
Emergencies
Technology
Intermittent parathyroid hormone injection can decrease femoral head collapse in the vascular deprivation of rat femoral head model
Chiang, C. W., Chen, W. C., Lee, C. H. & Chen, C. H., 三月 1 2019, 於 : Indian Journal of Orthopaedics. 53, 2, p. 340-346 7 p.研究成果: 雜誌貢獻 › 文章
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Thigh
Parathyroid Hormone
Blood Vessels
Osteogenesis
Injections
2
引文
(Scopus)
Internal workplace violence from colleagues is more strongly associated with poor health outcomes in nurses than violence from patients and families
研究成果: 雜誌貢獻 › 文章
Workplace Violence
Domestic Violence
Nurses
Health
Violence
Intervening Nidal Brain Parenchyma and Risk of Radiation-Induced Changes After Radiosurgery for Brain Arteriovenous Malformation: A Study Using an Unsupervised Machine Learning Algorithm
Lee, C. C., Yang, H. C., Lin, C. J., Chen, C. J., Wu, H. M., Shiau, C. Y., Guo, W. Y., Hung-Chi Pan, D., Liu, K. D., Chung, W. Y. & Peng, S. J., 五月 1 2019, 於 : World Neurosurgery. 125, p. e132-e138研究成果: 雜誌貢獻 › 文章
Radiosurgery
Arteriovenous Malformations
Radiation
Brain
Cerebrospinal Fluid
Intestinal parasitic infections: Current status and associated risk factors among school aged children in an archetypal African urban slum in Nigeria
Gyang, V. P., Chuang, T-W., Liao, C-W., Lee, Y-L., Akinwale, O. P., Orok, A., Ajibaye, O., Babasola, A. J., Cheng, P-C., Chou, C-M., Huang, Y-C., Sonko, P. & Fan, C-K., 2019, 於 : Journal of Microbiology, Immunology and Infection.研究成果: 雜誌貢獻 › 文章
Poverty Areas
Parasitic Diseases
Nigeria
Thimerosal
Drinking Water
1
引文
(Scopus)
Intranasal lidocaine for acute migraine: A protocol for the systematic review of randomized clinical trials
Chi, P. W., Hsieh, K. Y., Tsai, C. W., Hsu, C. W., Bai, C. H., Chen, C. & Hsu, Y. P., 五月 1 2019, 於 : Medicine. 98, 20, p. e15699研究成果: 雜誌貢獻 › 文章
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Lidocaine
Migraine Disorders
Randomized Controlled Trials
Safety
PubMed
1
引文
(Scopus)
Inverse association between statin use and head and neck cancer: A population-based case-control study in Han population
Kao, L. T., Hung, S. H., Kao, P. F., Liu, J. C. & Lin, H. C., 一月 1 2019, 於 : Head and Neck.研究成果: 雜誌貢獻 › 文章
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Head and Neck Neoplasms
Case-Control Studies
Population
Propensity Score
Investigating GABA concentrations measured with macromolecule suppressed and unsuppressed MEGA-PRESS MR spectroscopy and their relationship with BOLD responses in the occipital cortex
Duncan, N-W., Zhang, J., Northoff, G. & Weng, X., 十月 1 2019, 於 : Journal of Magnetic Resonance Imaging. 50, 4, p. 1285-1294 10 p.研究成果: 雜誌貢獻 › 文章
Occipital Lobe
gamma-Aminobutyric Acid
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Boidae
Investigating missed care by nursing aides in Taiwanese long-term care facilities
Tou, Y-H., Liu, M. F., Chen, S-R., Lee, P-H., Kuo, L-M. & Lin, P-C., 九月 17 2019, 於 : Journal of Nursing Management.研究成果: 雜誌貢獻 › 文章
Long-Term Care
Nursing Care
Patient Handoff
Nursing Process
Quality of Health Care
11
引文
(Scopus)
In vitro activities of cefiderocol, ceftolozane/tazobactam, ceftazidime/avibactam and other comparative drugs against imipenem-resistant Pseudomonas aeruginosa and Acinetobacter baumannii, and Stenotrophomonas maltophilia, all associated with bloodstream infections in Taiwan
Hsueh, S. C., Lee, Y. J., Huang, Y. T., Liao, C. H., Tsuji, M. & Hsueh, P. R., 二月 1 2019, 於 : Journal of Antimicrobial Chemotherapy. 74, 2, p. 380-386 7 p.研究成果: 雜誌貢獻 › 文章
Stenotrophomonas maltophilia
Acinetobacter baumannii
Imipenem
Taiwan
Pseudomonas aeruginosa
In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells
Chen, J. C., Hsieh, Y. Y., Lo, H. L., Li, A., Chou, C. J. & Yang, P. M., 九月 9 2019, 於 : Biomolecules. 9, 9研究成果: 雜誌貢獻 › 文章
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Drug Resistance
Computer Simulation
Colorectal Neoplasms
Etoposide
Topoisomerase Inhibitors
In Vitro and In Vivo Studies of Hydrophilic Electrospun PLA95/β-TCP Membranes for Guided Tissue Regeneration (GTR) Applications
Chen, C-C., Lee, S-Y., Teng, N-C., Hu, H-T., Huang, P-C. & Yang, J-C., 四月 11 2019, 於 : Nanomaterials. 9, 4, p. 599 599.研究成果: 雜誌貢獻 › 文章
Tissue regeneration
Electrospinning
Membranes
Surgery
Bone
Is frying oil a dietary source of an endocrine disruptor? Anti-estrogenic effects of polar compounds from frying oil in rats
Lin, Y. S., Lu, S. Y., Wu, H. P., Chang, C. F., Chiu, Y. T., Yang, H. T. & Chao, P. M., 三月 1 2019, 於 : Ecotoxicology and Environmental Safety. 169, p. 18-27 10 p.研究成果: 雜誌貢獻 › 文章
Unsaturated Dietary Fats
Endocrine Disruptors
Estrogen Receptors
Rats
Estrogens
Isolated compounds from turpinia formosana nakai induce ossification
Imtiyaz, Z., Wang, Y. F., Lin, Y. T., Liu, H. K. & Lee, M. H., 七月 1 2019, 於 : International Journal of Molecular Sciences. 20, 13, 3119.研究成果: 雜誌貢獻 › 文章
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osteogenesis
Osteogenesis
Bone
bones
osteoblasts
Isoliquiritigenin suppresses E2-induced uterine leiomyoma growth through the modulation of cell death program and the repression of ECM accumulation
Lin, P. H., Kung, H. L., Chen, H. Y., Huang, K. C. & Hsia, S. M., 八月 1 2019, 於 : Cancers. 11, 8, 1131.研究成果: 雜誌貢獻 › 文章
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Leiomyoma
Extracellular Matrix
Cell Death
Myometrium
Growth
1
引文
(Scopus)
Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata
Chen, M. C., Wang, G. J., Kuo, Y. H., Chiang, Y. R., Cho, T. Y., Ju, Y. M. & Lee, T. H., 一月 1 2019, 於 : Journal of Food and Drug Analysis. 27, 1, p. 111-117 7 p.研究成果: 雜誌貢獻 › 文章
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Xylaria
Isoptera
termite mounds
Ethers
nitric oxide
1
引文
(Scopus)
Isothermal titration calorimetry for characterization of recombinant proteins
Baranauskiene, L., Kuo, T. C., Chen, W. Y. & Matulis, D., 二月 1 2019, 於 : Current Opinion in Biotechnology. 55, p. 9-15 7 p.研究成果: 雜誌貢獻 › 回顧型文獻
Recombinant proteins
Calorimetry
Titration
Recombinant Proteins
Drug Design
5
引文
(Scopus)
Is temporo-spatial dynamics the “common currency” of brain and mind? In Quest of “Spatiotemporal Neuroscience”
Northoff, G., Wainio-Theberge, S. & Evers, K., 一月 1 2019, 於 : Physics of Life Reviews.研究成果: 雜誌貢獻 › 回顧型文獻
neurology
neurophysiology
Neurosciences
brain
Brain
1
引文
(Scopus)
Jagged1-expressing adenovirus-infected dendritic cells induce expansion of Foxp3 + regulatory T cells and alleviate T helper type 2-mediated allergic asthma in mice
Lin, C. L., Hsieh, C. L., Huang, H. M., Fan, C. K. & Lee, Y. L., 二月 1 2019, 於 : Immunology. 156, 2, p. 199-212 14 p.研究成果: 雜誌貢獻 › 文章
Regulatory T-Lymphocytes
Adenoviridae
Dendritic Cells
Asthma
Ovalbumin
3
引文
(Scopus)
Karnofsky performance status as a predictive factor for cancer-related fatigue treatment with astragalus polysaccharides (PG2) injection-A double blind, multi-center, randomized phase IV study
Wang, C. H., Lin, C. Y., Chen, J. S., Ho, C. L., Rau, K. M., Tsai, J. T., Chang, C. S., Yeh, S. P., Cheng, C. F. & Lai, Y. L., 一月 1 2019, 於 : Cancers. 11, 2, 128.研究成果: 雜誌貢獻 › 文章
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Karnofsky Performance Status
Second Primary Neoplasms
Fatigue
Polysaccharides
Injections
KDM4B is a coactivator of c-Jun and involved in gastric carcinogenesis
Wu, M. C., Cheng, H. H., Yeh, T. S., Li, Y. C., Chen, T. J., Sit, W. Y., Chuu, C. P., Kung, H. J., Chien, S. & Wang, W. C., 二月 1 2019, 於 : Cell Death and Disease. 10, 2, 68.研究成果: 雜誌貢獻 › 文章
Interleukin-8
Stomach
Carcinogenesis
Epigenomics
Helicobacter pylori
3
引文
(Scopus)
KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC
Wang, H. J., Pochampalli, M., Wang, L. Y., Zou, J. X., Li, P. S., Hsu, S. C., Wang, B. J., Huang, S. H., Yang, P., Yang, J. C., Chu, C. Y., Hsieh, C. L., Sung, S. Y., Li, C. F., Tepper, C. G., Ann, D. K., Gao, A. C., Evans, C. P., Izumiya, Y., Chuu, C. P. 及其他3, , 一月 3 2019, 於 : Oncogene. 38, 1, p. 17-32研究成果: 雜誌貢獻 › 文章
Pyruvate Kinase
Androgen Receptors
Androgens
Castration
Prostatic Neoplasms
2
引文
(Scopus)
Keratin scaffolds with human adipose stem cells: Physical and biological effects toward wound healing
Lin, C. W., Chen, Y. K., Tang, K. C., Yang, K. C., Cheng, N. C. & Yu, J., 六月 1 2019, 於 : Journal of Tissue Engineering and Regenerative Medicine. 13, 6, p. 1044-1058 15 p.研究成果: 雜誌貢獻 › 文章
Keratin
Scaffolds (biology)
Keratins
Stem cells
Scaffolds
Ketamine ameliorates severe traumatic event-induced antidepressant-resistant depression in a rat model through ERK activation
Lee, C. W., Chen, Y. J., Wu, H. F., Chung, Y. J., Lee, Y. C., Li, C. T. & Lin, H. C., 七月 13 2019, 於 : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 93, p. 102-113 12 p.研究成果: 雜誌貢獻 › 文章
Extracellular Signal-Regulated MAP Kinases
Ketamine
Antidepressive Agents
Serotonin Uptake Inhibitors
Depression
Knee joint function, walking ability and quality of life within 6 weeks after total knee arthroplasty: A prospective cohort study
Chang, S. Y., Lin, L. H. & Lin, P. C., 九月 2019, 於 : Journal of Clinical Nursing. 28, 17-18, p. 3222-3232 11 p.研究成果: 雜誌貢獻 › 文章
Knee Replacement Arthroplasties
Knee Joint
Walking
Cohort Studies
Quality of Life
Knowledge of and Attitudes Toward Advance Directives in Patients With Advanced Heart Failure
Liao, M. Y., Lee, J. J., Smith, R. & Lin, C. C., 二月 1 2019, 於 : Journal of Hospice and Palliative Nursing. 21, 1, p. 80-89 10 p.研究成果: 雜誌貢獻 › 文章
Advance Directives
Heart Failure
Confidence Intervals
Ambulatory Care Facilities
Social Class
Labour pain control by aromatherapy: A meta-analysis of randomised controlled trials
Chen, S. F., Wang, C. H., Chan, P. T., Chiang, H. W., Hu, T. M., Tam, K. W. & Loh, E. W., 八月 1 2019, 於 : Women and Birth. 32, 4, p. 327-335 9 p.研究成果: 雜誌貢獻 › 文章
Aromatherapy
Labor Pain
Meta-Analysis
Randomized Controlled Trials
Third Labor Stage
Lactobacillus paracasei PS23 decelerated age-related muscle loss by ensuring mitochondrial function in SAMP8 mice
Chen, L. H., Huang, S. Y., Huang, K. C., Hsu, C. C., Yang, K. C., Li, L. A., Chan, C. H. & Huang, H. Y., 一月 1 2019, 於 : Aging. 11, 2, p. 756-770 15 p.研究成果: 雜誌貢獻 › 文章
Sarcopenia
Muscles
Reactive Oxygen Species
Muscle Strength
Control Groups
Lamotrigine augmentation in treatment-resistant unipolar depression: A comprehensive meta-analysis of efficacy and safety
Goh, K. K., Chen, C. H., Chiu, Y. H. & Lu, M. L., 六月 1 2019, 於 : Journal of Psychopharmacology. 33, 6, p. 700-713 14 p.研究成果: 雜誌貢獻 › 文章
Treatment-Resistant Depressive Disorder
Depressive Disorder
Meta-Analysis
Safety
Depression
2
引文
(Scopus)
Large circular plasmids from groundwater plasmidomes span multiple incompatibility groups and are enriched in multimetal resistance genes
Kothari, A., Wu, Y. W., Chandonia, J. M., Charrier, M., Rajeev, L., Rocha, A. M., Joyner, D. C., Hazen, T. C., Singer, S. W. & Mukhopadhyay, A., 一月 1 2019, 於 : mBio. 10, 1, e02899-18.研究成果: 雜誌貢獻 › 文章
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Groundwater
Plasmids
Genes
Microbiota
Metals