9-Cis-retinoic acid reduces ischemic brain injury in rodents via bone morphogenetic protein

Hui Shen, Yu Luo, Chi Chung Kuo, Xiaolin Deng, Chen Fu Fang, Brandon K. Harvey, Barry J. Hoffer, Yun Wang

研究成果: 雜誌貢獻文章

29 引文 斯高帕斯(Scopus)

摘要

Retinoic acid (RA), a biologically active derivative of vitamin A, has protective effects against damage caused by H2O2 or oxygen-glucose deprivation in mesangial and PC12 cells. In cultured human osteosarcoma cells, RA enhances the expression of bone morphogenetic protein-7 (BMP7), a trophic factor that reduces ischemia- or neurotoxin-mediated neurodegeneration in vivo. The purpose of this study is to examine whether RA reduces ischemic brain injury through a BMP7 mechanism. We found that intracerebroventricular administration of 9-cis-retinoic acid (9cRA) enhanced BMP7 mRNA expression, detected by RT-PCR, in rat cerebral cortex at 24 hr after injection. Rats were also subjected to transient focal ischemia induced by ligation of the middle cerebral artery (MCA) at 1 day after 9cRA injection. Pretreatment with 9cRA increased locomotor activity and attenuated neurological deficits 2 days after MCA ligatiom 9cRA also reduced cerebral infarction and TUNEL labeling. These protective responses were antagonized by the BMP antagonist noggin given 1 day after 9cRA injection. Taken together, our data suggest that 9cRA has protective effects against ischemia-induced injury, and these effects involve BMPs.

原文英語
頁(從 - 到)545-555
頁數11
期刊Journal of Neuroscience Research
87
發行號2
DOIs
出版狀態已發佈 - 二月 1 2009
對外發佈Yes

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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    Shen, H., Luo, Y., Kuo, C. C., Deng, X., Fang, C. F., Harvey, B. K., Hoffer, B. J., & Wang, Y. (2009). 9-Cis-retinoic acid reduces ischemic brain injury in rodents via bone morphogenetic protein. Journal of Neuroscience Research, 87(2), 545-555. https://doi.org/10.1002/jnr.21865